Phase 3 Ovarian Cancer Trial, Recruiting NCT07225270 Sponsor: Genmab Condition: Ovarian Cancer
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Phase 3 Ovarian Cancer Trial, Recruiting

NCT07225270
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with a specific type of ovarian cancer, primary peritoneal cancer, or fallopian tube cancer, confirmed through laboratory testing of tissue or cell samples (specifically high-grade serous or endometrioid types).
  • People whose cancer came back more than 6 months after finishing their first course of platinum-based chemotherapy (a type of cancer treatment).
  • People with a BRCA gene mutation or a related DNA repair problem (called HRD-positive) whose cancer responded well to first-line platinum-based chemotherapy must have also received a type of maintenance medication called a PARP inhibitor as part of that first treatment course.
  • People who have completed a second course of platinum-based chemotherapy for their returned cancer.
  • People who are enrolled in the trial no later than 8 weeks after their last dose of that second course of platinum-based chemotherapy.
  • People whose cancer responded to the second course of chemotherapy — either by disappearing completely, partially shrinking, or remaining stable (stable disease is only considered if a drug called bevacizumab was also given during that second course).

Who may not be able to join:

  • People whose ovarian cancer is of a specific tissue type, including clear cell, mucinous, sarcomatous, mixed tumours containing any of these types, or low-grade/borderline ovarian tumours.
  • People who have received more than 2 previous rounds of systemic cancer treatment.
  • People whose cancer got worse either during or after their second course of platinum-based chemotherapy, before being enrolled in the trial.
  • People who received any additional systemic cancer treatment (other than bevacizumab) between finishing their second course of platinum-based chemotherapy and being enrolled in the trial.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Study Official, Genmab

Phone: +4570202728

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
Genmab
Registry
ClinicalTrials.gov
Start date
3 April 2026
Est. completion
1 October 2028

Where this trial is recruiting

🇯🇵 Japan 🇺🇸 United States

Primary endpoints

Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumours (RECIST) 1.1, as Determined by Blinded Independent Central Review (BICR)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov