Phase 3 Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to sign a consent form before any assessments take place.
• People aged 18 to 65 years old (inclusive) at the time of screening.
• People who have been diagnosed with Secondary Progressive Multiple Sclerosis (SPMS) according to a specific set of medical criteria (the 2017 revised McDonald criteria).
• People who have had no recorded MS relapses (sudden worsening of symptoms) in the 24 months before screening.
• People whose level of disability, as measured by a standard MS scale called the EDSS, falls between 3.0 and 6.0 at the time of screening (confirm with trial site what this means for your situation).
• People who have documented evidence that their disability has been getting worse in the 12 months before screening.

Who may not be able to join:

• People who are unwilling or unable to have MRI scans, for example due to claustrophobia or having certain metal implants, a pacemaker, or a defibrillator in their body.
• People who have a significant history of other brain or nervous system conditions, such as stroke, traumatic brain or spinal injury, or other conditions that could look similar to MS.
• People with ongoing drug or alcohol misuse, or serious mental health conditions that could affect their ability to follow the study procedures.
• People who have previously been diagnosed with a serious brain infection called Progressive Multifocal Leukoencephalopathy (PML), or who have had neurological symptoms that could suggest PML.
• Women who are physically capable of becoming pregnant, unless a highly effective form of contraception (less than 1% failure rate per year) is used throughout the study treatment period and for at least one week after stopping treatment.
• People who have significant problems with bleeding or blood clotting at the time of screening.
• People who are taking certain medications that are listed as excluded in the trial protocol (confirm with trial site which medications apply).
• Additional criteria not listed here may also apply, as noted in the full trial protocol.

Important: Always verify eligibility with the trial site directly before applying.