Motor Neurone Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with idiopathic Parkinson's disease (a common form of Parkinson's not caused by another condition).
• People whose Parkinson's medication has remained the same for the past month and is expected to stay the same for the next 3 months.
• People who are able to walk more than 50 metres without using a walking aid such as a cane, walker, or crutches.

For the control group (people without Parkinson's disease):

• People whose age (within 3 years) and sex are similar to those of participants in the Parkinson's group.
• People who are able to walk more than 50 metres without using a walking aid.

Who may not be able to join:

• People who are unable to demonstrate the capacity to give informed consent, as assessed using specific standardised tools.
• People who have a history of a significant brain or nervous system condition (other than Parkinson's disease, for those in the Parkinson's group).
• People who have a history of stroke, traumatic brain injury, a brain aneurysm, bleeding in the brain, a brain tumour, or an atypical form of Parkinson's-like disorder.
• People with a severe bone, joint, or muscle condition that significantly affects the way they walk.
• People who are pregnant or may be pregnant.
• People who do not have sufficient understanding of the English language.
• People with a history of substance abuse within the past 2 years.

Additional criteria for the part of the trial involving nerve stimulation on the neck (nVNS):

• People who experience pain, unusual skin sensations, or nerve pain at the side of the neck where the stimulation device would be applied.
• People who have a wound, rash, infection, swelling, skin condition, surgical scar, or abnormal anatomy at the stimulation site, or who have had previous neck surgery such as carotid artery surgery.
• People with known or suspected serious heart or artery conditions, including severe narrowing of the carotid arteries, heart failure, severe coronary artery disease, or a previous heart attack.
• People who have had an abnormal heart tracing (ECG) within the past year, including certain irregular heart rhythms or conduction problems (confirm with trial site).
• People with a recent history of uncontrolled high blood pressure, an unusually slow or fast heart rate, or a known history of a sudden drop in blood pressure when standing up.
• People who have previously had a surgical procedure to cut the vagus nerve on one or both sides.
• People who have metal implants or medical devices in or near the neck or head, such as a deep brain stimulator, pacemaker, hearing implant, metal spinal hardware, implanted defibrillator, aneurysm clips, neurostimulator, valve replacements, stents, or metallic prostheses near the stimulation site.
• People who have a history of fainting episodes or seizures within the past 2 years.

Important: Always verify eligibility with the trial site directly before applying.