Phase 3 Schizophrenia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are comfortable reading, speaking, and understanding English
• Your score on a thinking and memory test suggests an IQ of 70 or above
• You have been living in the community (not in a hospital or inpatient facility) for at least one month before joining the study
• Your medications have been at a stable dose for at least one month before joining, with no major changes in the past 30 days and no changes at all in the 7 days before taking the study drug

Who may not be able to join:

• You have a major brain or nervous system disorder (such as epilepsy or multiple sclerosis)
• You have had a head injury at any point in your life, with or without losing consciousness
• You have any serious medical condition that the study doctor believes could put you at risk or make it hard to participate
• You have a history of kidney problems, kidney disease, or kidney injury
• You have a history of liver problems, liver disease, or liver injury
• You have a history of heart attack or heart disease
• You have heart-related symptoms — such as shortness of breath, a racing or fluttering heartbeat, difficulty breathing when lying down, swollen feet or ankles, severe dizziness, fainting, or leg pain when walking — that the study doctor believes could put you at risk
• You have a low white blood cell count, or have been diagnosed with a condition affecting white blood cells (such as leukopenia, neutropenia, or agranulocytosis)
• Your blood pressure is uncontrolled and above 140/90, or your resting heart rate is above 100 beats per minute
• Your blood or urine lab results fall outside the normal ranges set by the study (confirm with trial site for specific values)
• You are currently pregnant, trying to become pregnant, or breastfeeding
• You cannot pass a basic vision test (needing to see at least 20/25 with or without glasses)
• You currently take certain medications or supplements that could interact dangerously with the study drug, modafinil — for example, ketamine, certain antidepressants (MAOIs), diazepam, propranolol, warfarin, amphetamines, methylphenidate, or clomipramine (confirm with trial site for a full list)
• You are allergic to modafinil
• You are already taking modafinil as a prescribed medication
• You have previously had a severe skin reaction called Stevens-Johnson syndrome after taking any medication
• You have had a significant problem with alcohol or drug use in the past 3 months
• You have ever had a stimulant use disorder (such as a serious problem with amphetamines or cocaine) at any point in your life
• You are currently considered at clinical risk for suicide, have active thoughts of suicide, have made a plan to act on suicidal thoughts in the past 6 months, or have made a suicide attempt in the past 6 months
• You have been experiencing a depressive episode in the past month, as identified through a diagnostic interview or assessment
• You have been diagnosed with, or meet the criteria for, a psychotic disorder, bipolar disorder, or autism spectrum disorder
• You have a parent, sibling, or child who has been diagnosed with a psychotic disorder, bipolar disorder, or autism spectrum disorder
• You currently take any psychiatric medications or supplements that affect mood or thinking (such as nootropics)
• You have any other mental health symptoms or conditions that, in the study doctor's opinion, could put you at risk or affect your ability to participate
• You are unwilling or unable to give informed consent to take part in the study
• You are unable to show that you can make an informed decision about joining the study, in the judgment of the study staff
• You are unable to read or write
• You have taken part in significant brain training or cognitive training programs in the past year, in the opinion of the study doctor (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.