Prostate Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are 40 years of age or older
- People who have had a prostate MRI scan (pMRI) within the last 12 weeks
- People whose general health and activity level falls within a certain range, rated 0 or 1 on a standard scale used by doctors (confirm with trial site)
- People whose prostate MRI showed a "PIRADS 3" finding, AND whose PSA blood test result is 3.0 ng/ml or higher (for those aged 40–75), or 4.0 ng/ml or higher (for those over 75)
- People whose prostate MRI showed a "PIRADS 1 or 2" finding, AND whose PSA level meets the thresholds above, AND who also have at least one of the following: a high PSA density result (0.15 ng/ml/g or higher); a suspicious physical prostate exam (DRE); a positive or high-risk result on a blood or urine biomarker test; Black or African American ancestry; an inherited gene mutation linked to higher prostate cancer risk; a significant personal medical history (confirm with trial site); a significant family history of prostate cancer (confirm with trial site); or a PSA level that has stayed elevated for at least 12 months and doubled within 24 months, confirmed on two separate tests
- Men of all ethnic groups and races are eligible
Who may not be able to join:
- People under 18 years of age
- People whose prostate MRI showed a "PIRADS 4 or 5" finding
- People who have already been diagnosed with clinically significant prostate cancer based on a biopsy result (Gleason score of 7 or higher)
- People who have been diagnosed with prostate cancer and are already being managed through active surveillance, surgery, or radiation — though an exception may apply for people who have never had a prostate MRI before, whose biopsy only ever showed a low-grade result (Gleason score 6), and who currently need a follow-up biopsy (confirm with trial site)
- People who are not medically suitable for anesthesia
- People with a history of allergic reactions to contrast agents (dyes used in scans) or chemically similar substances
- People with a medical condition that would prevent them from safely having a prostate MRI or a prostate biopsy
- People with a medical condition that could affect the quality of the MRI images, such as an artificial hip replacement or significant gas in the bowel
- People with any other condition that the trial investigator believes could interfere with safely taking part in the study
- Women will not be included in this trial
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Ahmet M Aydin, MD, University of Arkansas
Phone: 5016868274
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Acceptance rate of randomization and biopsy recommendations based on study protocol and AI algorithm results by the patients; Per-patient and per-lesion csPCa detection rates of AI algorithm-informed biopsy (the intervention arm) versus contemporary biopsy (the control arm) in patients randomly allocated 1:1 to each arm
Can't join this trial?
Data last synced from ClinicalTrials.gov: 7 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.