Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with localised prostate cancer, confirmed through tissue testing (biopsy).
• People who have a lymph node in the pelvic area that shows up on a PSMA scan and measures less than 1 centimetre across at its narrowest point.
• People who have not yet received any definitive treatment for their prostate cancer.
• People who are generally able to carry out basic daily activities, as measured by a standard health scoring tool, assessed within 14 days before joining the trial (confirm with trial site).
• People aged 30 years or older.
• People who are able to give informed consent before the trial begins.
• People who are able to swallow medications.

Who may not be able to join:

• People whose cancer has spread beyond the pelvic lymph nodes to other parts of the body, including to bones within the pelvis.
• People who have personal, family, social, or location-related circumstances that may make it difficult to follow the trial schedule, including issues related to alcohol or drug dependence.
• People who have medical reasons why radiation therapy would not be safe for them, such as inflammatory bowel disease, certain connective tissue conditions like lupus or scleroderma, or genetic conditions that increase sensitivity to radiation (confirm with trial site).
• People with serious, active health conditions, including any of the following:
  • Unstable chest pain or heart failure that required a hospital stay in the past 3 months.
  • Heart failure that noticeably limits physical activity or is more severe (confirm with trial site).
  • A heart attack that affected the full thickness of the heart wall within the past 3 months.
  • A stroke or mini-stroke within the past 3 months.
  • Diabetes that is currently not under control.
  • Certain serious heart rhythm problems that are not stable; note that stable atrial fibrillation managed with blood thinners is generally permitted (confirm with trial site).
  • A blood clot in a vein or lung within the past month.
  • Serious blood vessel disease, such as a large aortic aneurysm or significant circulation problems in the limbs.
  • An active bacterial or fungal infection that requires intravenous antibiotics at the time of joining.
  • A serious flare-up of a lung condition, or any breathing illness that required hospitalisation or would prevent participation in the trial at the time of joining.
  • Liver problems causing yellowing of the skin or eyes, or affecting the blood's ability to clot.
  • AIDS (as defined by current health authority guidelines) being treated with certain specific medications that are not compatible with this trial; note that HIV testing is not required to join (confirm with trial site).
  • Seizures that are not well controlled, or any seizure within the past 3 months; people whose seizures have been well managed on medication for more than 3 months may still be considered (confirm with trial site).
  • A significant bleeding event within the past 30 days.
  • A wound, ulcer, or bone fracture that has not healed within the past 90 days.
  • Certain abnormal liver blood test results above specified levels (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.