Phase 1 Eczema Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For all participants (Part A and Part B):

• People aged between 18 and 65 years old
• People with a body mass index (a measure of body weight relative to height) between 18 and 28, and who weigh no more than 120 kg
• Women who could become pregnant must have a negative pregnancy test
• People who are willing to avoid alcohol for 24 hours before each study visit
• People who do not smoke, smoke no more than 5 cigarettes per day, or who have previously smoked but no longer do
• People who are using adequate contraception (applies to both men and women who could become pregnant)
• People with no significant medical conditions or relevant medical history

For Part B participants only (in addition to the above):

• People who have had atopic dermatitis (a type of chronic eczema) for at least 12 months, confirmed by a dermatologist
• People whose atopic dermatitis has not responded well enough to skin-based treatments, or for whom those treatments are not medically appropriate
• People with moderate to severe atopic dermatitis
• People whose dermatologist rates their condition at a score of 3 or higher on a recognised severity scale (vIGA-AD™) (confirm with trial site)
• People whose eczema-affected skin covers at least 10% of their body surface area
• People who have reported an average itch score of 4 or higher (on a scale of 0–10) over the 7 days before being assigned to a treatment group
• People who score 16 or higher on a recognised eczema severity measurement tool (EASI) at both their initial check and their treatment assignment visit

Who may not be able to join:

For all participants (Part A and Part B):

• People with significant health conditions such as diabetes, HIV, hepatitis B or C, immune system disorders, autoimmune diseases, cancer, or a history of conditions that increase the risk of infections
• People with a significant history of metabolic, skin, liver, kidney, blood, or other major health disorders
• People with notably abnormal blood test results, including low blood counts, liver abnormalities, or impaired kidney function
• People who test positive for drugs or alcohol, or who have abnormal vital signs (such as blood pressure or heart rate) at the screening visit or the day before the study begins
• People with abnormal heart tracing (ECG) results
• People with a history of drug or alcohol misuse in the past 2 years
• People who have donated more than 500 mL of blood in the 2 months before screening
• People with a history of severe allergic reactions or serious hypersensitivity

For Part B participants only (in addition to the above):

• People who have skin conditions other than atopic dermatitis, or who have significant tattoos or scarring that may affect assessment
• People who have received immunoglobulin or blood products within the 30 days before the study
• People whose atopic dermatitis affects their eyes, or who regularly use steroid eye drops or ointments
• People who experience chronic itch caused by a condition other than atopic dermatitis
• People with active, recently treated, or ongoing chronic skin infections
• People currently using sedating antihistamines or corticosteroid medications

Important: Always verify eligibility with the trial site directly before applying.