Crohn's Disease and Colitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender
• People who have had a confirmed diagnosis of inflammatory bowel disease (IBD) — either Crohn's disease, ulcerative colitis, or a type called IBDU — for at least 6 months before the study starts
• People who have been on a medication called ustekinumab for at least 14 weeks, or who stopped taking it within the past 12 weeks
• People who stopped ustekinumab and have not started any other advanced IBD medication since stopping
• People whose IBD has not responded well enough to ustekinumab, and whose treating doctor has decided to start them on a medication called guselkumab
• People who have had a recent bowel camera test (colonoscopy) within the past 3 months showing active signs of disease — with specific activity scores or visible ulcers, depending on whether the diagnosis is Crohn's disease or ulcerative colitis (confirm with trial site for exact score thresholds)
• People who are willing and able to give written consent and follow the study requirements

Who may not be able to join:

• People who have previously taken certain IBD medications called anti-p19 inhibitors, specifically risankizumab or mirikizumab
• People for whom guselkumab is medically unsuitable according to the official drug guidelines
• People who did not receive the standard starting doses (induction) of guselkumab, or who are taking it in a non-standard way
• People who have a stoma (a surgically created opening in the abdomen) or an internal pouch created after bowel surgery
• People who have had bowel surgery within the 6 months before the study starts
• People who have had signs of a severe flare-up of ulcerative colitis, a very serious bowel inflammation (fulminant colitis), or a dangerous bowel complication (toxic megacolon) within the past 3 months
• People whose IBD doctor expects them to need bowel surgery within the year of joining the trial
• People currently taking more than one biologic medication at the same time
• People with a history of precancerous changes or cancer in the colon (note: a result of "indefinite for dysplasia" does not automatically exclude someone — confirm with trial site)
• People who are unable or unwilling to have a bowel camera examination (colonoscopy)
• People whom the trial doctor considers unsuitable for the study for any reason

Important: Always verify eligibility with the trial site directly before applying.