Phase 3 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to give your consent to take part in the study.
• You are between 60 and 90 years old (any gender).
• You have been diagnosed with mild to moderate Alzheimer's disease, AND either: you have been taking memantine (20 mg daily) for at least 2 months (Groups 1 & 2), OR you have not been taking any Alzheimer's medications for the past 2 or more months (Group 3).
• Your score on a standard memory and thinking test called the MMSE falls between 10 and 23.
• Your score on another cognitive assessment called the ADAS-Cog falls between 20 and 54.
• A brain scan (CT or MRI) shows no signs that your dementia is caused by problems with blood flow to the brain.
• A test called the Modified Hachinski Ischemic Scale shows a score below 7, suggesting your dementia is not related to blood vessel problems.
• You have a caregiver who spends a significant amount of time with you, is willing to come to all study visits with you, help you take the study medication, and fill out a diary about your health.
• You are able to follow all the requirements of the study.

Who may not be able to join:

• You have another illness that is known to cause dementia (such as severe thyroid problems, severe anemia, a brain tumour, or a brain infection).
• You have a history of other brain or nervous system conditions, such as Parkinson's disease, multiple sclerosis, uncontrolled epilepsy, hallucinations, or other conditions that seriously affect your movement or thinking.
• You have had an allergic or bad reaction to any ingredient in the study drug in the past.
• You have a history of stroke.
• You currently have an active cancer.
• You are expected to need surgery on the blood vessels in your neck or brain during the study period.
• You have a significant uncontrolled health condition that the study doctor believes would prevent your safe participation, including serious problems with your lungs, heart, kidneys, liver, hormonal system, or digestive system.
• You have a systemic autoimmune disease (such as lupus) that requires or has required treatment with systemic medications.
• You had a heart attack within the 12 months before joining the study.
• You have a known ongoing infection such as hepatitis, HIV, tuberculosis, or syphilis.
• Your doctors expect you to live less than one year.
• You have taken certain medications that can affect memory or thinking (such as some antidepressants, sleeping pills, or antipsychotics), or certain other prohibited medications, within 1 month before the study start.
• You have moderate to severe depression, as measured by a score of 18 or more on the Hamilton Depression Scale.
• You are a smoker.
• You have had issues with alcohol or drug misuse in the past 6 months.
• The study doctor believes you would not be able to follow the study procedures, even with help.
• You have taken part in another clinical trial within the past 6 months.
• You have another serious or unstable mental health condition that could affect your ability to safely take part or to give informed consent.

Important: Always verify eligibility with the trial site directly before applying.