Phase 2 Asthma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old
• People with a confirmed asthma diagnosis, with a documented history of asthma for at least 1 year, where the diagnosis was made before age 40, and/or whose lung function test results fall within a specific range (confirm with trial site)
• People whose asthma symptoms are not well controlled despite using a combination inhaler (containing both a steroid and a long-acting reliever), as measured by a standard asthma control score below 20
• People who have not had a severe asthma episode in the past 3 months that required steroid tablets, an emergency department visit, or a hospital stay
• People who are able to learn and correctly use two types of inhalers (a pressurised metered dose inhaler and a dry powder inhaler)
• People who are willing and able to follow study procedures, including lung function tests performed sitting and lying down, and who understand the risks involved
• Women who could potentially become pregnant and who are willing to use a highly effective form of contraception from the time of signing the consent form until the follow-up visit, or whose partner has been confirmed by a doctor to be unable to father children (in which case contraception is not required)
• Women who cannot become pregnant, defined as those who have gone through menopause (no periods for 12 or more consecutive months without another medical cause) or who have had a permanent sterilisation procedure such as removal of the uterus, fallopian tubes, or ovaries
• People who give written consent before any study-related procedures take place

Who may not be able to join:

• People who are pregnant or breastfeeding
• People who had a significant worsening of asthma symptoms in the 3 months before the first study visit that required steroid tablets, antibiotics, or hospitalisation
• People who are unable to complete lung function tests or follow the study procedures and treatment requirements
• People with a history of a life-threatening asthma attack or a past stay in an intensive care unit for asthma, where the trial doctor judges this may place the person at undue risk
• People who have used steroid tablets, injections, or slow-release steroid medications within a certain period before screening (4 weeks for regular steroids, 12 weeks for slow-release forms)
• People who have been diagnosed with a chronic lung disease known as COPD
• People with a history of cystic fibrosis, bronchiectasis, alpha-1 antitrypsin deficiency, or any other significant lung condition that could interfere with study results
• People who currently smoke or use e-cigarettes, or who have a significant smoking history (10 or more pack-years), or who stopped smoking within one year before the screening visit
• People with a clinically significant heart condition, including moderate-to-severe heart failure, a recent heart attack (within the past year), certain heart rhythm problems diagnosed in the last 6 months, significant electrical conduction problems in the heart, or a type of irregular heartbeat called atrial fibrillation (confirm specific details with trial site)
• People who are unable to undergo CT or MRI scans, or who have a known intolerance to Xenon gas
• People who have taken part in another clinical treatment trial within the past 6 months
• People who have an allergy to milk protein

Important: Always verify eligibility with the trial site directly before applying.