Phase 1 Motor Neurone Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Your Body Mass Index (BMI) — a measure of body weight relative to height — must be 18 or above.
• You must have been diagnosed with ALS (also known as Lou Gehrig's disease) with symptoms, confirmed using a specific set of diagnostic guidelines called the Gold Coast criteria.
• For participants without a family history of ALS: you must have tested negative for known gene changes that are linked to inherited (familial) ALS.
• For a specific group in this trial (Cohorts 2 and 3 only): you must have a confirmed change in a gene called SOD1 that is known to cause ALS, and must have tested negative for other gene changes linked to inherited ALS.
• Any other gene variations found may need to be reviewed by the trial organisers to check if you are still eligible (confirm with trial site).
• Your score on a standard ALS symptom and function rating scale (called the ALSFRS-R) must be 24 or higher at the start of the trial.
• You must have been living with ALS for 42 months (3.5 years) or less since your symptoms began.

Who may not be able to join:

• You cannot join if you have previously received cell therapy or gene therapy as a treatment for ALS.
• You cannot join if you are currently taking or have recently taken any experimental medication or been part of another clinical trial, whether for ALS or any other condition.

Important: Always verify eligibility with the trial site directly before applying.