Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who weigh at least 40 kilograms (about 88 pounds)
• People who have acute leukemia that has come back or stopped responding to treatment, and whose leukemia has a specific change in one of these genes: KMT2A, NPM1, NUP98, or NUP214 — and for whom other treatment options have been tried or are not suitable
• People who are generally able to carry out daily activities with little to no limitation (measured by a standard health scale called ECOG grade 0 or 1)
• People who have regular bowel movements, meaning at least one bowel movement every two days on average
• Women who could become pregnant must have a negative pregnancy blood test at the start of the trial and again within 48 hours before the first dose of the study treatment

Who may not be able to join:

• People who have a specific type of leukemia called acute promyelocytic leukemia, or leukemia linked to Down syndrome (as defined by WHO 2016 guidelines)
• People who have active disease affecting the brain or spinal cord
• People who have previously received a solid organ transplant (such as a kidney, liver, or heart transplant)
• People who still have significant side effects from previous cancer treatments that have not returned to their normal baseline or reduced to a mild level — with the exception of hair loss, stable nerve symptoms, or certain low blood count issues
• People who have had a major operation requiring general anaesthesia within the two weeks before the first dose, who have not yet recovered from a recent major surgery, or who have a major surgery planned during the time the study treatment would be given

Important: Always verify eligibility with the trial site directly before applying.