Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Arm 1 (various cancer types):

• People with a confirmed diagnosis of classical Hodgkin lymphoma or primary mediastinal large B-cell lymphoma that has come back or stopped responding to treatment, with disease that can be measured on scans
• People with skin melanoma (Stage IIB, IIC, III, or IV) that has been completely removed by surgery, with no prior drug-based treatments for melanoma, and where any suspicious areas have been tested and confirmed cancer-free
• People with locally advanced (cannot be surgically removed) or metastatic (spread to other parts of the body) melanoma, including a type called acral melanoma, that cannot be treated with local therapies, with disease measurable on scans
• People with advanced or metastatic solid tumour cancers that have a specific genetic feature called MSI-H or dMMR, where standard treatments have failed, do not exist, or are considered unsuitable by the patient and their doctor, with disease measurable on scans
• People with advanced or metastatic solid tumour cancers that have a high number of genetic mutations (called TMB-H), where standard treatments have failed, do not exist, or are considered unsuitable, with disease measurable on scans
• People with a rare skin cancer called Merkel cell carcinoma (MCC) that has returned after surgery and/or radiation, cannot be treated locally, or has spread to other parts of the body, with disease measurable on scans
• People in Arm 1 must have a life expectancy of more than 3 months

Arm 2 (Merkel cell carcinoma only):

• People with advanced or metastatic Merkel cell carcinoma who have not yet received any treatment for their advanced or metastatic disease
• People in Arm 2 must have a life expectancy of more than 6 months

Who may not be able to join:

• People who have another cancer that is currently growing or has recently needed active treatment
• People with active cancer spread to the brain or the membranes surrounding the brain or spinal cord
• People with an autoimmune disease (where the immune system attacks the body) that has required medication to treat it within the past 2 years
• People with a history of lung inflammation (not caused by infection) that required steroid treatment, or who currently have this condition
• People with an active infection that requires medication to treat it
• People with a known history of HIV infection
• People with a known history of Hepatitis B, or an active Hepatitis C infection
• People who have ever had a solid organ transplant (such as a kidney or liver), or who received a bone marrow or stem cell transplant from a donor within the last 5 years
• People who have not fully recovered from a major surgery, or who have ongoing complications from a surgery

Important: Always verify eligibility with the trial site directly before applying.