Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been formally diagnosed with a lymphoid neoplasm (a type of blood cancer affecting lymph cells) according to current international classification standards
• People whose disease has come back, stopped responding to treatment, or did not respond well enough to standard treatment — this includes not responding after two rounds of first-line therapy, the disease getting worse within or after six months of treatment, or the disease returning after a stem cell transplant
• People who show signs of active Epstein-Barr virus (EBV) involvement — either through a high level of EBV detected in the blood, EBV-related markers found in tumour cells, or certain EBV antibody results in blood tests
• People who have at least one measurable area of lymphoma that can be tracked, or confirmed active EBV infection
• People aged 18 to 70 years, of any sex
• People with a general health and activity level rated as reasonably functional (ECOG score 0–2) and an expected survival of at least 3 months
• People whose blood counts meet minimum levels — including white blood cells, red blood cells, a specific type of immune cell (CD3+ T-cells), and platelets
• People whose kidneys, liver, and heart are functioning within acceptable ranges — including kidney filtration rate, liver enzyme levels, bilirubin, heart pumping function (at least 50%), no significant fluid around the heart, no major heart rhythm problems, minimal fluid around the lungs or abdomen, and blood oxygen levels of at least 95%
• Women who could become pregnant must have a negative pregnancy test and agree to use effective contraception until the end of follow-up
• Men with partners who could become pregnant must agree to use effective contraception until the end of follow-up
• People who are mentally and emotionally stable, able to understand the trial's purpose, and willing to give signed informed consent and follow the trial requirements

Who may not be able to join:

• People with active hepatitis A, B, or C, or any other severe active infection that is not under control (EBV infection itself is not excluded)
• People with a history of AIDS (acquired immunodeficiency syndrome)
• People who regularly take immunosuppressant medications — including steroid doses higher than the equivalent of 15 mg per day of prednisone — for ongoing conditions
• People with serious heart problems, including severe heart failure (NYHA Class III or IV), a heart attack or heart bypass surgery in the past 6 months, significant irregular heart rhythms, unexplained fainting, a history of severe non-ischemic cardiomyopathy, or poor heart pumping function (below 45%) within 8 weeks before a blood collection procedure
• Women who are pregnant or breastfeeding
• People who are not willing to use contraception during the trial
• People with liver or kidney function that does not meet the required levels (liver enzymes or bilirubin too high, or kidney filtration rate below the minimum threshold)
• People with a known history of severe allergic reactions to any of the study drugs
• People who have had a stem cell transplant must have stopped immunosuppressant medications for more than 6 weeks before joining, and must show no signs of graft-versus-host disease (GVHD)
• People with any other condition that the trial doctor considers makes participation unsuitable, such as clotting disorders or a condition where the body breaks down its own red blood cells (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.