Phase 3 Motor Neurone Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with definite or probable ALS (also known as Lou Gehrig's disease), confirmed using a standard set of diagnostic guidelines called the El Escorial criteria.
- Your ALS symptoms started no more than 18 months before your screening appointment.
- Your lungs are working at 60% or more of the expected level for someone of your age and size, measured by a breathing test called slow vital capacity.
- Your score on a specific ALS risk and survival prediction calculator (called the TRICALS Risk Profile, based on the ENCALS model) falls between -6 and -2 at your screening appointment (confirm with trial site if unsure what this means for you).
- You are able to swallow a capsule.
Who may not be able to join:
- You have a tracheostomy (a breathing tube in your throat) or are on permanent breathing support.
- You have a serious heart condition, a history of significant irregular heartbeat, uncontrolled atrial fibrillation, a certain type of rapid heartbeat (ventricular tachycardia), or a specific heart electrical abnormality called left bundle branch block.
- You have an unstable mental health condition, significant memory or thinking problems, dementia, or a substance use problem that could affect your ability to consent to or take part in the study.
- You have another significant or unstable health condition (other than ALS) that could put you at risk or affect your ability to complete the study.
- You are currently taking any medications known to affect the heart's electrical rhythm in a specific way (called QT interval prolongation) (confirm with trial site).
- You have previously been treated with pridopidine, gene therapy, or a type of drug called antisense oligonucleotides.
- You have a confirmed genetic mutation in the SOD1, FUS, or C9orf72 gene.
- You are pregnant.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 857-574-5755
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change from baseline through Week 26 and Week 48 in the Revised ALS Functional Rating Scale (ALSFRS-R) total score adjusted for mortality
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.