Phase 2 Asthma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old (any gender)
• You have been diagnosed with bronchial asthma — this includes a new diagnosis, or asthma first diagnosed in childhood or teenage years that has become more noticeable or worse in adulthood
• Breathing tests before joining the trial show your lung function is within a specific moderate range (60%–85% of what is expected for someone your age and size)
• Within the past year, at least one test has shown that your airways have variable airflow limitation — for example, your breathing improved significantly after using a reliever inhaler, your airways reacted to a trigger substance during a test, or your peak flow readings varied by more than 10% on average over 7 days
• You are willing and able to sign a consent form agreeing to take part

Who may not be able to join:

• You are unable to use a nebuliser (a device that turns liquid medicine into a mist to breathe in), cannot tolerate this type of treatment, or did not pass training on how to use it correctly
• You have another lung condition such as COPD, bronchiectasis, pulmonary fibrosis, or tuberculosis (confirm with trial site if your asthma is still considered the main condition)
• You have another significant condition that affects how your lungs work, such as problems with the chest wall, diaphragm, or muscles involved in breathing
• You have a history of serious heart problems such as heart failure, coronary artery disease, heart attack, irregular heartbeat, or consistently high blood pressure that is not controlled
• You have an overactive thyroid (hyperthyroidism) that the doctor feels makes it unsafe for you to join
• You have a serious history of blood, liver, psychiatric, kidney, or other diseases that the doctor feels would put you at risk or affect the results
• You have had a cancer diagnosis in the past 5 years (some exceptions may apply — confirm with trial site)
• You have had, or are expected to need, an organ or bone marrow transplant within the next year
• Your blood test during screening shows low potassium levels
• You have Type 1 diabetes, or Type 2 diabetes that is not well controlled (with a fasting blood sugar above a certain level during screening)
• You currently have a fungal infection in your mouth, throat, or food pipe (candidiasis)
• Your liver or kidney function tests during screening are above a certain level of abnormality
• You have active hepatitis B or hepatitis C infection (at certain levels in the blood), HIV, or a history of AIDS
• You are known to be allergic to inhaled corticosteroids (steroid inhalers) or salbutamol (a common reliever inhaler)
• You have had a respiratory infection, sinus infection, or middle ear infection within 4 weeks before or during the run-in period that the doctor feels could affect your asthma
• Your asthma has gotten significantly worse and needed steroid tablets or injections within 4 weeks before or during the run-in period, or you are currently taking oral (swallowed) steroids for asthma or another condition
• You have taken, or need to take during the trial, certain strong medications that affect how the body breaks down drugs (called strong CYP3A4 inhibitors — examples include ritonavir, ketoconazole, and clarithromycin; confirm with trial site)
• You stopped smoking less than 1 year ago, or you have a smoking history of more than 10 pack-years (this includes cigarettes, cigars, pipes, and e-cigarettes)
• You have had problems with drug misuse or alcohol dependence in the past 2 years (heavy alcohol use is defined as more than 2 standard drinks per day on average)
• You are pregnant, breastfeeding, or planning to become pregnant during the trial
• You have taken part in another clinical trial within the past month
• The doctor running the trial has another reason they feel makes it unsuitable for you to join

Important: Always verify eligibility with the trial site directly before applying.