Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given their written agreement to take part in this specific study before enrolling
• People who have been diagnosed with prostate cancer (a specific type called adenocarcinoma), confirmed through a tissue sample test
• People whose prostate cancer is classified as "intermediate-risk" according to a standard set of guidelines used by cancer specialists (called NCCN criteria)
• People whose doctors have determined they are medically suitable to receive a standard course of external beam radiation therapy to the prostate, and — for one group in the trial — who are also able to tolerate several injections into the prostate guided by ultrasound
• People aged 18 or older
• People who are reasonably active and able to care for themselves, based on a standard medical scoring system (rated 0, 1, or 2 on the ECOG scale — confirm with trial site if unsure what this means)
• For one group in the trial only, people whose blood test results meet certain minimum levels for liver enzymes, kidney function, and blood cell counts (the trial site will check these specific values)

Who may not be able to join:

• People with active liver disease, such as cirrhosis or active hepatitis
• People currently taking high-dose steroid medications (more than 10 mg of prednisone per day) or other medicines that suppress the immune system
• People known to be living with HIV
• People whose cancer has spread to nearby lymph nodes or to other parts of the body
• People who are planning to receive radiation treatment covering the whole pelvic area, rather than the prostate only
• People who currently have another type of cancer, with the exception of certain common skin cancers (squamous cell or basal cell)
• People with other serious health conditions or significant organ problems that, in the trial doctor's judgment, would interfere with treatment or follow-up — for example, severe prostate inflammation or inflammatory bowel disease, which can make radiation to the prostate unsuitable
• People who have previously received treatment for prostate cancer, except for a specific surgical procedure called a TURP (a procedure to clear a blocked urethra); people with a prior TURP may still be considered if the trial doctor determines they are able to receive the prostate injections
• People who have had, or are planning to have, surgical removal of the testicles as a form of hormone treatment
• For one group in the trial only, people with a known allergy or sensitivity to the medications acyclovir or valacyclovir

Important: Always verify eligibility with the trial site directly before applying.