Phase 1 Cervical Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to sign a consent form agreeing to take part in the study.
• You are 18 years old or older when you join the trial.
• You are able to carry out basic daily activities, with any limitations ranging from fully active to capable of self-care but unable to work (confirm with trial site).
• Doctors expect you to live for at least 6 months.
• You have been diagnosed with locally advanced cervical cancer (at a specific stage) through a tissue or cell sample, and surgery cannot fully remove the cancer.
• You are planned to receive a combination of radiation therapy and chemotherapy as your main treatment.
• You have at least one tumor that can be measured on a scan.
• Your blood counts are healthy enough — including white blood cells, platelets, and hemoglobin — without needing recent transfusions or injections to boost them.
• Your kidneys are working well enough, and your urine does not contain too much protein.
• Your liver is working well enough, including healthy levels of liver enzymes and proteins in your blood.
• Your blood clotting is within an acceptable range (or within the right range if you are already on blood thinners).
• Your heart is pumping well enough (heart pumping strength of at least 50%).
• If you are a woman who could become pregnant, you have a negative pregnancy test within 3 days before starting the study drug, and you agree to use reliable contraception during the study and for 120 days after your last dose.
• If you are a man who could father a child, you agree to use reliable contraception during the study and for 120 days after your last dose.
• You are willing and able to attend appointments and follow the study plan.

Who may not be able to join:

• You have difficulty swallowing, problems absorbing food, uncontrolled vomiting, or are being fed through a tube or directly into a vein; or you have an eating disorder or severe pain that makes eating very difficult.
• You are currently taking or planning to take medications that increase appetite or weight, such as certain steroids (outside of short-term use during chemotherapy), hormones, or other appetite-stimulating drugs.
• You have been diagnosed with Cushing's syndrome, adrenal or pituitary gland problems, or diabetes that is not well controlled.
• There is current evidence that your digestive tract is blocked.
• You have an active autoimmune disease that has needed treatment within the past two years, or you have had or currently have a type of lung inflammation that required steroid treatment.
• You have serious ongoing illnesses that are not under control, such as severe liver disease, kidney failure, uncontrolled metabolic conditions, severe stomach ulcers, or mental health or social issues that would make it hard to follow the study.
• In the past 12 months, you have had serious heart problems such as unstable chest pain requiring hospital admission, a heart attack, significant heart failure, or dangerous irregular heartbeat; or in the past 6 months, you have had bleeding from stomach or oesophagus veins, a serious stomach or bowel perforation, a hole or tear in the digestive tract, an abscess inside the abdomen, or active gastrointestinal bleeding.
• In the past 6 months, you have had a blood clot in an artery, a serious blood clot in a vein needing urgent treatment, a mini-stroke or stroke, or a severe blood pressure crisis; or in the past month, you have had a sudden worsening of a long-term lung condition (COPD); or your blood pressure is currently too high even with medication (160/100 mmHg or above).
• You have a history of serious bleeding problems, or in the past month you have had significant bleeding such as coughing up blood, heavy nosebleeds, or gastrointestinal bleeding.
• In the past 4 weeks, you have had a serious infection requiring hospital treatment, or in the past 2 weeks you have had an active infection needing antibiotic or antifungal treatment (treatment for hepatitis B or C is an exception).
• You have any other condition, treatment, or abnormal test result that the study team believes could affect the results or make the study unsafe for you (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.