Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part voluntarily, agree to follow the study requirements, and sign a consent form
• People aged 18 to 75 years (any sex)
• People whose general health and ability to carry out daily activities falls within a certain range, as measured by a standard medical scale (ECOG score of 0–1; confirm with trial site)
• People who have been confirmed through laboratory testing of tissue samples to have a specific type of esophageal cancer called squamous cell carcinoma, before any surgery
• People whose cancer is located in the chest portion of the oesophagus (food pipe)
• People whose cancer cannot be fully removed by surgery — this includes cancer that has grown into nearby structures, cancer with certain lymph node involvement, or cases where the surgeon has determined surgery is not feasible (confirm with trial site for full details)
• People who have never previously received any cancer treatment, including chemotherapy, hormone therapy, radiation therapy, or immunotherapy
• People whose recent blood test results (taken within 7 days before joining) show that blood counts, liver function, kidney function, blood clotting, thyroid function, and heart pumping strength all fall within the required ranges (confirm specific values with trial site)
• Women who agree to use contraception during the study and for 6 months afterward, have a negative pregnancy test within 7 days before joining, and are not breastfeeding; and men who agree to use contraception during the study and for 6 months afterward
• People who have no psychological, family, social, or location-related factors that could make it difficult to follow the study plan

Who may not be able to join:

• People whose cancer has spread to distant parts of the body, other than to lymph nodes near the collarbone
• People who have, or are at high risk of, a tear or hole in the oesophagus
• People for whom radiation therapy or certain immunotherapy drugs (called immune checkpoint inhibitors) are medically unsuitable
• People who previously had serious side effects from immunotherapy drugs
• People who received radiation therapy to the chest, abdomen, or pelvis within the 6 months before joining
• People who still have side effects from previous cancer treatment that have not sufficiently settled down (unless the trial doctors consider those effects to pose no safety risk)
• People with active infections (bacterial, viral, or fungal) that are not well controlled despite treatment
• People with breathing difficulties, airway blockage, or low oxygen in the body's tissues
• People with significant heart disease (classified as NYHA Class II or higher; confirm with trial site)
• People with markedly abnormal liver or kidney function (certain test results more than 3 times the upper limit of normal)
• People with active hepatitis B, hepatitis C, HIV, or syphilis
• People with active brain disease, cancer that has spread to the brain or surrounding membranes with significant symptoms, or difficulties with decision-making
• People with known allergies to any of the drugs used in this trial
• People with current drug or alcohol misuse
• Women who are pregnant or breastfeeding
• People who are currently taking part in another treatment-based clinical trial
• People who had a major surgical procedure within 30 days before joining
• People who used antibiotics, antifungal, antiviral, or antiparasitic medications within 4 weeks before joining

Important: Always verify eligibility with the trial site directly before applying.