Eczema Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women between the ages of 40 and 60 years old
• People who have a non-infectious, non-autoimmune inflammatory skin condition on the face (such as rosacea, acne, or eczema), either self-reported or diagnosed by a doctor
• People who are willing and able to drink a small daily drink (either a probiotic drink or skimmed milk) every day for 8 weeks
• People who are willing and able to provide blood, skin, and stool samples at the start and end of the study, and who are able to give enough blood for testing (those who cannot provide enough blood will not be able to start)
• People who are willing to have anonymised photographs taken of their face for the study
• People who are able to attend clinic visits at King's College London and follow the study procedures
• People who have access to a refrigerator at home and can safely store the study drinks after collecting them
• People who are able to give written consent to take part
• People who have a sufficient level of English to complete the study questionnaires and assessments

Who may not be able to join:

• People who are unwilling or unable to give informed consent to participate
• People who are unwilling or unable to follow the study requirements, such as attending clinic visits, providing samples, or drinking the daily study drink
• People who are unwilling to keep handwritten records of what they eat during the study
• People who are not sufficiently fluent in English
• People who are planning to travel internationally during the study period
• People who are currently taking part in another clinical trial, or who have taken an investigational or pharmaceutical product in the past 3 months
• People who have a known allergy or intolerance to dairy products, skimmed milk, or probiotic drinks containing Lactobacillus bacteria
• People who are currently pregnant, currently breastfeeding, or planning to become pregnant in the next 4 months
• People whose body mass index (a measure of body weight relative to height) is below 18.5 or above 35 (confirm with trial site)
• People who have unintentionally lost more than 4 kg in weight in the 3 months before joining the study
• People who have had issues with substance abuse or heavy alcohol use (more than 50 units of alcohol per week) in the past 12 months
• People who currently smoke, or who stopped smoking within the last 6 months
• People whose fasting blood sugar level is above a certain threshold, as measured by a finger-prick test at the first clinic visit (confirm with trial site)
• People who have had an active skin infection requiring antibiotics, antiviral, or antifungal medication taken by mouth or injection in the past 4 weeks
• People who have a major bowel or digestive condition (such as inflammatory bowel disease or coeliac disease), or who have had significant bowel surgery (not including appendix or gallbladder removal)
• People with a known condition that weakens the immune system, or who take high-dose immune-suppressing medication (confirm with trial site)
• People who have had cancer or a significant non-cancerous skin condition in the past 5 years (except for certain treated forms of skin cancer — confirm with trial site)
• People with serious medical conditions that, in the opinion of the study doctor, could affect safety or interfere with the study results (such as uncontrolled diabetes, advanced heart, liver or kidney disease, active cancer, or autoimmune conditions)
• Women with a history of severe psychiatric illness that may make it difficult to follow the study requirements
• People who are currently using probiotic or prebiotic supplements, or who have taken antibiotics in the 4 weeks before the start of the study
• People who are currently using, or have used in the past 3 months, steroid tablets or other immune-suppressing or immune-modifying medicines
• People who are currently receiving, or have received in the past 3 months, light-based treatments for a skin condition (such as UVB therapy, laser treatment, or similar, including home-use devices)
• People who are currently receiving, or have received in the past 3 months, prescription medicines taken by mouth or injection for skin conditions that affect the immune system or skin inflammation (such as isotretinoin, methotrexate, cyclosporine, or biologic medicines)
• People who are currently using, or have used in the past 3 months, strong prescription creams or ointments applied to the skin that significantly affect skin inflammation (such as high-strength steroid creams, certain calcineurin inhibitor creams, or topical retinoids)
• People who are currently using, or have used in the past 3 months, skincare products containing probiotics (such as creams or serums)
• People who have had, are currently having, or are planning to have cosmetic skin procedures (such as chemical peels, laser therapy, dermal fillers, or microneedling) within 3 months before or after the first study visit
• People who are currently using, or have used in the past 3 months, certain hormonal contraceptives or hormonal treatments that are known to affect skin conditions (such as the Mirena coil, the progesterone-only pill, or certain synthetic hormones — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.