Phase 3 Type 2 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People whose body mass index (BMI — a measure of body weight relative to height) is 30 or above, OR whose BMI is between 27 and 30 and who also have at least one weight-related health condition, such as prediabetes, high blood pressure, high cholesterol, sleep apnea, or weight-related heart disease.
• People who have made at least one previous attempt to lose weight through diet or exercise that did not succeed, based on self-report.
• People who are able to give themselves an injection of the study drug, or who can receive the injection from a trained person if they have a visual impairment or physical limitation.

Who may not be able to join:

• People with a history of Type 1 or Type 2 diabetes, or a history of diabetic ketoacidosis or hyperosmolar coma (a serious diabetes-related emergency) — though a past diagnosis of gestational diabetes (diabetes during pregnancy) may be acceptable if no diabetes has been recorded since.
• People whose body weight has changed by more than 5 kg (about 11 pounds) in the three months before screening.
• People whose weight problems are caused by a hormonal disorder (such as Cushing's syndrome) or by a specific genetic condition linked to obesity (such as Prader-Willi syndrome).
• People who have previously had, or are planning to have, surgery to treat obesity — though liposuction or a tummy tuck performed more than one year before screening may be acceptable.
• People with a known significant problem with how their stomach empties food, such as severe gastroparesis (confirm with trial site).
• People with a history of acute or chronic pancreatitis (inflammation of the pancreas) or significant gallbladder disease — though prior pancreatitis caused by gallstones or gallbladder disease may be acceptable if the gallbladder was surgically removed at least three months before screening.
• People with poorly controlled high blood pressure at the time of screening.
• People who have had a heart attack, stroke, mini-stroke (TIA), unstable chest pain (angina), or a hospital stay due to heart failure within the three months before screening.
• People with a history of significant or unstable major depression, schizophrenia, bipolar disorder, or other serious mood or anxiety disorders — though people with stable major depression or generalised anxiety disorder that has been stable for at least one year may be considered, depending on their medications and the opinion of the trial investigator.
• People who have been treated with a type of weight-loss or diabetes medication known as a GLP-1 receptor agonist (such as certain injectable medications used for weight management or blood sugar control) within six months before joining the trial.

Important: Always verify eligibility with the trial site directly before applying.