Phase 3 Osteoarthritis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Your Body Mass Index (BMI) is 27 or higher (a measure of weight relative to height) at the time of screening
• Your weight has been fairly stable — changing less than 5% — for the past 3 months before screening
• You have tried at least one diet to lose weight in the past but were not successful
• You have osteoarthritis of the knee AND at least one of the following: you are over 50 years old, you experience morning knee stiffness lasting around 30 minutes, or you have a crackling or grinding sensation in your knee

Who may not be able to join:

• You have had, or are planning to have, surgery specifically to treat obesity (note: certain cosmetic procedures like liposuction may be allowed if done more than 1 year before screening — confirm with trial site)
• You have had, or are planning to have, a procedure or device-based treatment aimed at treating obesity (a past device may be acceptable if it was removed more than 6 months before screening — confirm with trial site)
• You have any type of diabetes, including type 1 or type 2
• You currently have an active infection in your knee
• You have had a heart attack, stroke, a procedure to open blocked heart arteries, unstable chest pain, or been hospitalised for heart failure within the past 90 days
• You have been diagnosed with the most severe category of heart failure (Class IV), which severely limits physical activity
• You have taken any prescription or alternative medicines intended to help with weight loss within the past 90 days before screening

Important: Always verify eligibility with the trial site directly before applying.