Phase 2 Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old (any sex)
• People who have had an ischemic stroke (a stroke caused by a blocked blood vessel) confirmed by a brain scan (CT or MRI)
• People where no more than 36 hours have passed between when stroke symptoms first started and when the study treatment would be given — for strokes noticed upon waking, the clock starts from the last time the person was seen to be well
• People whose stroke severity falls within a specific range on a standard medical scale (NIHSS score between 8 and 20, meaning a moderate stroke) (confirm with trial site)
• People — or their legally authorised representative — who are willing to take part and agree to sign a consent form

Who may not be able to join:

• People who have already received clot-dissolving medication through a drip (IV thrombolysis) or a procedure to physically remove a clot (mechanical thrombectomy) before the study treatment is given
• People who had some level of disability before the stroke occurred, as measured on a standard disability scale (modified Rankin Scale score of 2 or higher) (confirm with trial site)
• People who currently have bleeding in or around the brain, brain tumours, abnormal blood vessels in the brain, multiple sclerosis, a history of serious brain injury, brain infection, or other conditions that can cause stroke-like symptoms
• People who are unable to have a CT or MRI brain scan
• People with a significantly reduced level of consciousness at the time of screening
• People with serious existing neurological or psychiatric conditions that would make it difficult to follow the trial procedures
• People with a body temperature above 38°C before treatment is given, where the treating doctor considers there to be a risk of infection
• People with an active infection that cannot be controlled, or people who have had systemic antibiotics or other anti-infective treatment in the 7 days before the study treatment and where the doctor considers there is a short-term risk of this becoming uncontrollable
• People with severe heart failure or severe breathing failure
• People with serious kidney disease (where kidney filtration rate falls below a specific level) (confirm with trial site)
• People with advanced liver disease, such as serious hepatitis or liver cirrhosis
• People with certain hepatitis B or C markers in their blood, or who test positive for syphilis antibodies or HIV antibodies
• People with high blood pressure that is not controlled by medication, where readings reach or exceed 185/110 mmHg
• People with blood sugar levels that are either too low or too high (outside a specific range) (confirm with trial site)
• People whose blood test results show liver enzyme levels, kidney markers, blood cell counts, or clotting measures outside acceptable ranges as defined by the trial (confirm with trial site for specific values)
• People with cancer or any other condition where life expectancy is less than 2 years
• People with immune system deficiencies (either present from birth or acquired), or people currently taking medications that suppress the immune system
• People with alcohol dependence or a history of drug misuse
• Women who are pregnant or breastfeeding, or people who plan to conceive, donate sperm, or donate eggs during the trial and who are unwilling to use effective contraception
• People who have taken part in another clinical trial within the past month before screening
• People who are allergic to any ingredient in the study treatment
• People the treating doctor considers unsuitable for the trial for any other reason

Important: Always verify eligibility with the trial site directly before applying.