Phase 2 Stroke Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 18 years of age or older
- You have had an acute stroke caused by a blood clot within the last 3 hours, and have already received the standard clot-dissolving treatment given through a vein (IV)
- You had a measurable level of stroke-related neurological symptoms before receiving the first clot-dissolving treatment, based on a standard stroke severity score (NIHSS score of 4 or higher)
- Your symptoms have not improved significantly, or got worse after initial improvement, one hour after the first clot-dissolving treatment, and a brain scan has confirmed there is no bleeding in the brain
- A second dose of the clot-dissolving treatment can be given within 4.5 hours of when your stroke symptoms first started
- This is your first stroke, or you have had a previous stroke but recovered well with little to no lasting disability
- You are willing and able to sign a consent form agreeing to take part in the trial
Who may not be able to join:
- You are planned to have a procedure to physically remove the clot from inside a blood vessel
- You have significant changes to the white matter in your brain shown on a brain scan (a high Fazekas score of 3) (confirm with trial site)
- You have a blood clotting problem, including certain abnormal blood test results (such as INR above 1.5), identified before the first clot-dissolving treatment
- You are pregnant
- You have a known allergy to the medication being tested in this trial
- You have taken two different blood-thinning/anti-clotting tablets together in the 24 hours before receiving the clot-dissolving treatment
- You have other serious health conditions alongside your stroke
- You have taken part in another clinical trial within the last 3 months
- The trial doctor has determined for any other reason that you are not suitable for this study
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
proportion of excellent functional outcome (modified Rankin Scale (mRS) 0-1)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 2 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.