Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For people with Subjective Cognitive Decline (SCD):

• Men and women aged between 55 and 70 years
• People who speak German as a native language
• People who have noticed a decline in their own memory or thinking abilities, but whose cognitive test results are within the normal range
• People who are still fully independent in their daily activities
• People who do not have dementia
• People who are willing and able to provide written consent to take part

For people with Mild Cognitive Impairment (MCI):

• Men and women aged between 55 and 70 years
• People who speak German as a native language
• People where a change in memory or thinking has been noticed — either by themselves, a family member, or a clinician — and where memory test scores fall at least 1.0 standard deviation below the normal range on a specific memory test (the Wechsler Logical Memory Scale)
• People who are still largely independent in their daily activities
• People who do not have dementia
• People who are willing and able to provide written consent to take part

For healthy controls (people with no memory concerns):

• Men and women aged between 55 and 70 years
• People who speak German as a native language
• People who do not report any concerns about their memory or thinking
• People who are willing and able to provide written consent to take part

Who may not be able to join:

• People who are not able to give informed written consent to participate
• People who are currently taking polyamine supplements or who have taken part in a related supplement study
• People who have been diagnosed with dementia (as defined by DSM-IV criteria)
• People with any condition that would interfere with completing the cognitive or clinical assessments used in the study (confirm with trial site)
• People who have diabetes mellitus
• People who have polycystic ovary syndrome
• People with a history of epilepsy, a focal brain lesion, or a head injury that caused loss of consciousness or confusion
• People who have previously had a stroke
• People with severe untreated medical problems or an unstable medical condition
• People currently experiencing a major depressive episode
• People with a psychotic disorder
• People with bipolar disorder
• People with a current or past history of substance abuse
• People with another neurodegenerative disease, such as Parkinson's disease
• People with vascular dementia
• People with a history of alcohol abuse
• People who have taken part in an interventional study within the last 3 months or who plan to participate in another study during this trial
• People with sleep disorders
• People currently taking medications that mainly affect the central nervous system, such as antipsychotics, antidepressants, benzodiazepines, over-the-counter sleep aids (such as valerian), or anti-dementia medications
• People with known intolerances or allergies to wheat germ, gluten, or histamine (this criterion applies to SCD and MCI participants; confirm with trial site whether it also applies to healthy controls)
• Healthy control participants who meet the criteria for Mild Cognitive Impairment (MCI)

Important: Always verify eligibility with the trial site directly before applying.