Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women between 18 and 70 years of age
• People whose overall health and ability to carry out daily activities meets a certain minimum standard, as measured by a scoring system doctors use (called an ECOG score of 0–1)
• People who have been confirmed through tissue testing to have invasive breast cancer at a specific stage (T1cN1-2M0 or T2-3N0-2M0), where the cancer is hormone receptor-positive and has a particular level of a protein called HER2 (described as "HER2-low"), as defined by specific medical guidelines
• People whose cancer tissue has been tested for a marker called PD-L1 using a specific laboratory method
• People who have not received any cancer treatment before joining the trial
• People whose major organs (such as the heart, liver, and kidneys) are functioning at a level that meets the trial's required standards
• Women who have not yet gone through menopause or had surgical sterilisation, and who are willing to use effective contraception throughout treatment and for at least 6 months after their last dose
• People who are willing to participate voluntarily, sign a consent form, follow the trial requirements, and attend follow-up appointments

Who may not be able to join:

• People whose breast cancer has spread to other parts of the body (stage IV)
• People diagnosed with inflammatory breast cancer
• People who have previously received cancer treatment or radiation therapy for any cancer (though some exceptions may apply for certain fully treated cancers such as cervical carcinoma in situ, basal cell carcinoma, or squamous cell carcinoma — confirm with trial site)
• People who are currently participating in another clinical trial that involves cancer treatment, including chemotherapy, hormone therapy, biological therapy, bone-strengthening drugs, or immune therapies
• People who had a major surgery unrelated to breast cancer within 4 weeks before starting the trial, or who have not fully recovered from such a surgery
• People with serious heart disease or significant heart-related problems
• People with active infections that are not under control and require treatment, a history of immune system disorders (including a positive HIV diagnosis), other inherited or acquired immune deficiencies, or a history of organ transplantation
• People with chronic active hepatitis B or active hepatitis C
• People who have previously received immunotherapy and experienced serious immune-related side effects — such as immune-related lung inflammation or heart muscle inflammation — that researchers believe could affect the safety of the trial medication
• People with a known allergy to any of the components of the medications used in this trial

Important: Always verify eligibility with the trial site directly before applying.