Osteoarthritis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 50 and 75 years old (any gender)
• Your body weight falls within a healthy-to-moderately-overweight range (BMI between 18 and 35)
• You have been diagnosed with knee osteoarthritis, including having had recurring knee pain in the past month plus at least two of the following: X-ray changes in the knee joint, being aged 50 or older, morning stiffness lasting 30 minutes or less, or a clicking/grating sensation when moving your knee
• Your knee osteoarthritis has been graded as mild to moderate (Grade I to III) on a knee X-ray taken within the last 6 months
• You have a moderate level of knee pain when walking on flat ground or climbing stairs, based on a standard pain scoring tool
• If you are already taking glucosamine or diacerein supplements, you are willing to keep the dose the same throughout the entire trial
• You have stopped taking all pain-relief medications for more than 2 weeks before joining, and agree not to take other pain relievers during the study (except for a specified rescue medication if needed)
• You are willing to take part fully in the trial and able to sign a consent form

Who may not be able to join:

• You have another condition causing knee pain, such as autoimmune arthritis, gout, joint infection, or a knee tumour
• You have pain elsewhere in your body that is worse than your knee pain, which could make it hard to assess the knee accurately
• Your knee joint has severely narrowed or the bones have fused together
• Your leg pain is caused by a back problem, such as a slipped disc or spinal narrowing
• You currently have a widespread or severe local infection
• You have significant abnormal results on infectious disease screening tests (confirm with trial site)
• You have had knee surgery, a serious knee injury in the past year, or a knee injection, radiotherapy, or keyhole surgery within the past 6 months
• You have had steroid injections into the knee, or have taken steroids or immune-suppressing drugs continuously for 2 or more weeks within the past 6 months
• You have taken Chinese herbal medicines or traditional Chinese medicine products for knee pain within the past month
• You have had physical therapies or applied topical treatments to your knee (such as acupuncture, cupping, heat patches, or plasters) within the past week
• You have a serious condition affecting your heart, brain, liver, kidneys, blood, hormones, or immune system
• You have or have had a malignant (cancerous) tumour
• You are planning to have elective knee surgery during the study period
• You have significant fluid build-up in the knee joint or severe swelling/circulation problems in your legs
• You need to take blood-thinning medications (with the exception of a stable low daily dose of aspirin up to 100 mg and/or clopidogrel)
• You have a condition affecting your consciousness or mental health that would prevent you from completing self-assessment questionnaires
• You have a history of drug abuse or heavy alcohol use
• You have a known allergy to any ingredients in the study product or comparison product, or a history of allergic reactions to protein-based drugs or foods
• You are pregnant, breastfeeding, have a positive pregnancy test, plan to become pregnant soon, or are unable to use reliable contraception during the study
• You have taken part in another clinical trial of a drug, biological product, or medical device within the past 3 months
• The trial team considers there to be any other reason you would not be suitable for this trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.