Phase 2 Oesophageal Cancer Trial, Recruiting NCT07410676 Sponsor: Essen Biotech Condition: Oesophageal Cancer
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Phase 2 Oesophageal Cancer Trial, Recruiting

NCT07410676
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Adults aged 18 or older
  • People with an advanced or metastatic solid tumour (a cancer that has spread) that has been confirmed by laboratory testing of tissue, and that has come back or stopped responding to standard treatments — or where no standard treatment exists
  • People whose cancer can be measured using standard imaging guidelines (known as RECIST v1.1 or iRECIST)
  • People who are generally well enough to carry out everyday activities, with a performance level that falls within the range the trial accepts (confirm specific level with trial site)
  • People whose blood counts, kidney function, liver function, heart function, and oxygen levels meet the trial's minimum thresholds (the trial site will assess these through blood tests and other checks)
  • People who have brain metastases (cancer that has spread to the brain) only if those areas have been stable for at least 3 months and do not currently require increasing doses of steroids to manage them

Who may not be able to join:

  • People who are pregnant or breastfeeding
  • People who need ongoing systemic (whole-body) medications that suppress the immune system, such as steroid tablets above a low dose, during the treatment period (some inhaled or skin-applied versions may be permitted — confirm with trial site)
  • People with an active autoimmune disease that requires systemic immune-suppressing treatment
  • People with an uncontrolled bacterial, fungal, or viral infection
  • People who have received another experimental treatment within 28 days before the first dose in this trial
  • People who have received a live vaccine within 6 weeks before the preparatory treatment phase of the trial
  • People who are HIV positive, or who have active hepatitis B or C with detectable virus levels in their blood (some cases of chronic, symptom-free hepatitis may be considered — confirm with trial site)
  • People with a known allergy to any ingredient in the trial treatment, such as albumin or DMSO
  • People with any medical or personal circumstances that the trial team considers likely to affect safe participation or the ability to follow the trial requirements

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: 2077706670

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Essen Biotech
Registry
ClinicalTrials.gov
Start date
1 February 2026
Est. completion
21 December 2028

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Incidence and severity of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs); Incidence of Dose-Limiting Toxicities (DLTs)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov