Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older
• People who have been diagnosed with follicular lymphoma (a type of slow-growing blood cancer) that has come back or stopped responding to treatment, confirmed by a tissue sample test
• People who have already received at least two previous rounds of cancer treatment, including at least one treatment that targeted a protein called CD20 on cancer cells
• People who are generally well enough to carry out daily activities (the trial uses a standard medical scale to measure this, rated 0 or 1 out of 4)
• People who have at least one measurable area of disease larger than 1.5 cm
• People whose life expectancy is estimated by their doctor to be at least 18 weeks
• People whose side effects from previous cancer treatments have mostly cleared up (to a mild level or below), apart from hair loss or reduced appetite
• People whose liver is functioning adequately, based on blood test results within accepted ranges
• People whose blood counts (white blood cells, platelets, and red blood cells) are within acceptable levels, without having needed a blood or platelet transfusion very recently
• People whose kidneys are functioning adequately, based on blood test results
• Women who could become pregnant must have a negative pregnancy test within 7 days before starting treatment, and must agree to avoid pregnancy during the study through abstinence or effective contraception
• Men must agree to avoid fathering a child during the study through abstinence or effective contraception

Who may not be able to join:

• People who are unable to follow the requirements of the trial, including any required hospital stays or restrictions
• People who have an active infection or a latent (inactive but present) tuberculosis infection
• People who have had a serious allergic reaction to medicines in the same drug class as the trial treatment
• People whose lymphoma has spread to the brain or spinal cord
• People who are pregnant or breastfeeding
• People with serious uncontrolled health conditions, such as heart disease or immune system disorders, or who have had a heart attack, dangerous irregular heartbeat, or unstable chest pain within the past 6 months
• People with a history of illicit drug use or alcohol misuse within the 12 months before screening, based on the doctor's assessment
• People with any other medical condition, abnormal test result, or health finding that the trial doctor believes makes the trial treatment unsuitable for them
• People with a psychiatric condition or memory/thinking difficulties that may prevent them from understanding or following the trial requirements
• People (or their partners) planning to become pregnant during the study period
• People whom the trial doctor considers unsuitable for participation for any other reason

People already enrolled may be excluded from the trial's results analysis if:

• It is discovered after joining that they did not meet the eligibility criteria
• They had previously been treated with zanubrutinib or similar drugs called BTK inhibitors
• They experienced intolerable side effects from zanubrutinib or similar drugs
• They received fewer than two doses of the trial treatment, making it impossible to assess whether it worked
• There were violations of the trial rules
• They had previously undergone a stem cell transplant using donor or their own stem cells

Important: Always verify eligibility with the trial site directly before applying.