Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women between 18 and 40 years old who want to protect their ability to have children in the future.
• People diagnosed with a pelvic cancer that requires radiation therapy, such as colon cancer, rectal cancer, anal cancer, or other cancers in the pelvic area.
• People who have clearly stated a wish to preserve their fertility and the ability to carry a pregnancy.
• People whose ovaries are working normally before the procedure, shown by specific hormone test results: FSH below 10 IU/L, LH within the normal range for reproductive age, AMH above 1 ng/mL, and Estradiol within the normal range for the follicular phase.
• People whose scans (CT, MRI, or PET) confirm the cancer has not spread to distant parts of the body.
• People with a Body Mass Index (BMI) below 35 (a measure of body weight relative to height).
• People who have read and signed a consent form agreeing to take part.

Who may not be able to join:

• People whose cancer is locally advanced or has spread to other parts of the body.
• People who have significant uterine (womb) problems, such as large fibroids, adenomyosis, or other conditions inside the womb that could complicate the procedure or a future pregnancy.
• People with serious heart conditions, including a heart attack within the last 6 months, very low heart pumping function (ejection fraction below 30%), severely uncontrolled high blood pressure, or severe narrowing of the aortic heart valve.
• People with poorly controlled diabetes, shown by an HbA1c (a blood sugar average test) above 9%, or persistently very high fasting blood sugar levels despite treatment.
• People with severe lung disease, including very low breathing capacity, low blood oxygen levels at rest, or high carbon dioxide levels in the blood.
• People with severe connective tissue disorders such as active lupus affecting the kidneys with poor kidney function, severe scleroderma affecting the lungs, or rheumatoid arthritis causing serious instability in the neck spine.
• People with a severe flare of inflammatory bowel disease (such as Crohn's disease or ulcerative colitis) combined with signs of significant malnutrition.
• People who depend on high-dose steroid medications (more than 20 mg of prednisone daily) and for whom reducing that dose before surgery is not possible.
• People who have previously received radiation therapy to the pelvic area.
• People who have previously received chemotherapy or immunotherapy that caused significant lasting side effects.
• People who are currently pregnant.
• People whose hormone test results suggest poor ovarian reserve (FSH above 10 IU/L, AMH below 1 ng/mL, or Estradiol outside the normal range).
• People who have medical reasons that make a future pregnancy unsafe, such as severe womb abnormalities or high risk of pregnancy complications.
• People with a BMI of 35 or above.
• People who are missing one of the blood vessels that supply the reproductive organs (gonadal vessels).
• People who, in the opinion of the lead researcher, are not suitable candidates for this procedure for any other reason (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.