Phase 1 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older at the time of signing the consent form
• You have been diagnosed with an advanced, inoperable, or spreading (metastatic) solid tumour, confirmed by a tissue or cell sample, and your cancer has come back or gotten worse during or after standard treatments — or standard treatments are not available or suitable for you
• You have at least one tumour that can be measured on a scan (note: if you have prostate cancer that has spread only to the bones, the trial team will discuss your case individually before deciding if you can join)
• Your doctors expect you to live for at least 3 more months
• You are in generally good physical condition, able to carry out daily activities with little or no limitation (as rated by a standard medical scale called ECOG score of 0 or 1), and this has been stable for at least 28 days before joining
• Your heart is pumping blood effectively, with a heart function score of at least 50%, confirmed by a heart scan done within the past 28 days

Who may not be able to join:

• You have previously received a treatment that specifically targeted a protein called B7-H3
• You have previously received a type of cancer drug called a topoisomerase inhibitor antibody-drug conjugate (for example, trastuzumab deruxtecan)
• You have heart failure with symptoms (confirm with trial site), or have a history of serious heart rhythm problems that needed treatment
• You had a heart attack or unstable chest pain (angina) within the 6 months before joining
• Your heart's electrical activity shows a specific abnormality (called a prolonged QTcF interval above 470 ms) based on three heart trace (ECG) tests (confirm with trial site)
• You are unable or unwilling to stop taking medications known to affect the heart's electrical rhythm
• You have a current or past history of lung inflammation or scarring (interstitial lung disease), or scans during screening suggest you might have this condition
• You have serious underlying lung problems, including a blood clot in the lungs within the past 3 months, severe asthma, severe chronic lung disease (COPD), restricted lung function, or you currently need extra oxygen
• You have an autoimmune, connective tissue, or inflammatory condition that affects the lungs (such as rheumatoid arthritis, Sjögren's syndrome, or sarcoidosis)
• You have an infection that is not under control and currently requires intravenous (IV) antibiotics, antiviral, or antifungal medicines
• You have an active and significant bacterial, fungal, or viral infection at screening, or you have Hepatitis C, HIV, or confirmed syphilis
• You have Hepatitis B (HBsAg positive) with virus levels above a certain threshold — though people with Hepatitis B may still be considered if they receive at least 2 weeks of anti-Hepatitis B treatment before starting the trial and agree to continue it during the study (confirm with trial site)
• You are currently breastfeeding, or you are pregnant (confirmed by a test taken within 7 days before joining) — women who are willing to temporarily stop breastfeeding are also excluded
• You have cancer that has spread to the spinal cord or brain in a way that is untreated, causing symptoms, or requiring steroid or anti-seizure medicines

Important: Always verify eligibility with the trial site directly before applying.