Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part and have signed a consent form agreeing to join the study
• You are between 18 and 75 years old (male or female)
• You have been diagnosed with a specific type of esophageal (food pipe) cancer called squamous cell carcinoma, confirmed by a tissue or cell sample
• Your cancer is at a certain stage — it has not spread to distant parts of the body, but may have spread to nearby lymph nodes or grown into surrounding tissue (confirm with trial site for exact staging)
• You have at least one area of cancer that can be measured on a scan, meeting specific size requirements
• Doctors believe your cancer can be fully removed by surgery (known as an R0 resection)
• You are generally able to carry out daily activities with little or no limitation (confirm with trial site)
• You have not had any previous treatment for your esophageal cancer, including surgery, radiotherapy, or chemotherapy
• You are planning to have surgery after completing the pre-surgery treatment in this trial
• You have no medical reasons preventing you from having surgery
• Your blood counts, liver function, kidney function, and blood clotting results are within acceptable ranges as confirmed by recent blood tests
• If you are a woman who could become pregnant, you have a negative pregnancy test within 72 hours before starting the trial and agree to use effective contraception during the trial and for at least 3 months after your last dose
• If you are a man whose partner could become pregnant, you agree to use effective contraception during the trial and for at least 3 months after your last dose
• You are willing and able to follow the study schedule and attend all required follow-up appointments

Who may not be able to join:

• Your cancer has grown significantly into nearby important structures such as major blood vessels or the windpipe
• You have fluid build-up around your lungs, heart, or abdomen that is uncontrolled and requires repeated draining
• You are underweight with a Body Mass Index (BMI) below 18.5 — though you may still be considered if your weight improves with nutritional support before joining (confirm with trial site)
• You have had a serious allergic reaction to monoclonal antibody medicines, or to any of the specific drugs used in this trial (adebrelimab, paclitaxel, cisplatin, or similar platinum-based medicines)
• You have previously had any cancer treatment, including radiotherapy, chemotherapy, immunotherapy, or targeted therapy
• You have taken strong immune-suppressing steroid medicines (above a certain dose) within the past 2 weeks — some lower-dose or topical steroids may be allowed (confirm with trial site)
• You have received a live vaccine within the past 4 weeks before starting the trial
• You have had major surgery or a serious injury within the past 4 weeks before starting the trial
• You have an active autoimmune disease (where your immune system attacks your own body), or a history of certain autoimmune conditions — some exceptions may apply, such as thyroid conditions well-controlled with medication or fully resolved skin or childhood allergy conditions (confirm with trial site)
• You have a weakened immune system, including a positive HIV test, any inherited or acquired immune disorder, or a history of organ or bone marrow transplant
• You have significant heart problems, including moderate-to-severe heart failure, unstable chest pain, a heart attack within the past year, or poorly controlled irregular heart rhythms
• You have had a serious infection within the past 4 weeks, or have signs of active infection or have needed antibiotic treatment (other than preventive antibiotics) within the past 2 weeks
• You have active tuberculosis (TB), had active TB within the past year, or had TB more than a year ago that was not properly treated
• You have a hereditary bleeding disorder or blood clotting problem, or have had significant bleeding episodes (such as gastrointestinal bleeding) within the past 3 months
• You have been diagnosed with another cancer within the past 5 years — some low-risk skin cancers or cervical pre-cancers that have been fully treated may be exceptions (confirm with trial site)
• You are currently pregnant or breastfeeding
• You have other serious medical or personal circumstances that the study doctor believes could make it unsafe for you to participate or prevent you from completing the study

**Important: Always verify eligibility with the trial site directly before applying