Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who identify as Chinese, are female, and are aged 18 or older but under 75 years old.
• People who have been diagnosed with early-stage breast cancer.
• People who have never previously received chemotherapy that carries a moderate or high risk of causing nausea and vomiting.
• People who are scheduled to receive their first round of breast cancer chemotherapy using one of two specific treatment combinations: either AC (Adriamycin and Cyclophosphamide) on a 14- or 21-day cycle, or FEC (Fluorouracil, Epirubicin, and Cyclophosphamide) on a 21-day cycle.
• People who have a life expectancy of at least 4 months.
• People whose general physical functioning is rated at 0 or 1 on a standard medical scale used to measure how cancer affects daily activities (confirm with trial site).
• People who are premenopausal must have a documented negative pregnancy test before joining.
• People who are able to read, understand, and fill in study questionnaires and a daily diary, including rating scales.
• People who understand what the study involves and are willing to give written consent to participate.

Who may not be able to join:

• People who have advanced (late-stage) breast cancer.
• People who are scheduled to receive cisplatin or any other chemotherapy with a higher nausea-and-vomiting risk than those listed in the study regimens.
• People who are scheduled to receive radiation therapy at the same time as their chemotherapy.
• People who experienced any vomiting, or moderate to severe nausea, in the 24 hours before their first day of chemotherapy.
• People who have previously been treated with chemotherapy that carries a moderate or high risk of causing nausea and vomiting.
• People who have an active infection (such as pneumonia or a serious fungal infection) or an uncontrolled medical condition (such as poorly controlled diabetes or high blood pressure) that, in the trial doctor's opinion, could affect the study results or create unnecessary health risks.
• People who have a history of glaucoma, dementia, seizures, Parkinson's disease, a serious drug reaction affecting the nervous system (Neuroleptic Malignant Syndrome), or blood clot-related conditions.
• People who currently use illicit drugs, including marijuana, or who show signs of alcohol misuse as assessed by the investigator.
• People who have a significant mental health or emotional condition that, in the trial doctor's opinion, would prevent safe participation in the study.
• People who regularly drink alcohol or smoke.
• People who have a history of any illness that, in the trial doctor's opinion, could affect study results or create unnecessary health risks.
• People who have had an allergic reaction to aprepitant, ondansetron, or dexamethasone (medications used in the study).
• People who have phenylketonuria (a specific metabolic condition) or abnormal uric acid levels.
• People who have taken any experimental medications within 4 weeks before the start of the study, or who are scheduled to take experimental medications during the study.

Important: Always verify eligibility with the trial site directly before applying.