Phase 2 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 50 years old or older, of any gender.
• You have been clinically diagnosed with Alzheimer's disease at a mild to moderate stage.
• You have had a spinal fluid test, a brain amyloid PET scan, or a specific blood test (p-tau217) within the past 3 years that supports an Alzheimer's diagnosis.
• You have had a brain MRI or CT scan within the past 6 months showing results consistent with mild to moderate Alzheimer's and no other major brain conditions (or you are able to get one before starting treatment).
• You scored between 10 and 24 (inclusive) on a standard memory and thinking test called the MMSE.
• You have a score of 4 or below on a test that checks for stroke-related factors (confirm with trial site).
• You have a reliable caregiver who can read and understand study documents, communicate with the study team, and spends at least 2 hours with you on at least 3 days per week.
• If you are a woman who could become pregnant, you must use effective birth control throughout the study.
• You have been taking your current Alzheimer's medications (such as donepezil, memantine, or similar) at the same dose for at least 60 days before joining, and you agree to keep the same dose throughout the study.
• You (or your legal guardian) are willing and able to sign a consent form and follow the study schedule.

Who may not be able to join:

• You have had a known allergic reaction to the study drug or similar drugs, or you have a history of severe allergies in general.
• You have previously received umbilical cord stem cell therapy.
• Your blood test results show problems with white blood cell counts, platelet counts, kidney function, or liver function outside of acceptable ranges (confirm with trial site).
• You cannot have an MRI scan due to having a pacemaker, metal implants, electronic devices in your body, or certain other medical devices (a full list should be confirmed with the trial site).
• You have another brain or neurological condition, such as Parkinson's disease, vascular dementia, epilepsy, multiple sclerosis, Huntington's disease, hydrocephalus, or a history of significant head injury.
• You have had a serious infection anywhere in your body within the 3 months before screening.
• You have tested positive for Hepatitis B, Hepatitis C, syphilis, or HIV.
• You have a history of alcohol or drug misuse, or a psychiatric illness, within the past 10 years.
• You have a history of cancer (malignant tumors).
• You have poorly controlled heart, liver, kidney, lung, hormone, or other major organ conditions.
• You have severe difficulty with speech, hearing, or vision, or other conditions that would make it impossible to complete memory and thinking tests.
• You have any serious illness where life expectancy is less than 12 months.
• You are currently pregnant, breastfeeding, or have a positive pregnancy test before the study starts.
• You are currently taking part in another clinical trial that could affect the results of this study.
• The study doctor feels there is any other reason participation would not be safe or appropriate for you.

Important: Always verify eligibility with the trial site directly before applying.