Phase 2 Schizophrenia Trial, Recruiting NCT07459647 Sponsor: MapLight Therapeutics Condition: Schizophrenia
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Phase 2 Schizophrenia Trial, Recruiting

NCT07459647
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who are willing and able to give informed consent for all parts of the study
  • People who have been diagnosed with schizophrenia according to standard diagnostic guidelines (DSM-5), confirmed through a structured clinical interview
  • People whose doctor (the investigator) believes would benefit from long-term medication treatment for schizophrenia
  • People whose doctor (the investigator) considers suitable for outpatient care and who live in a stable housing situation
  • People who have at least one trusted person (such as a family member, carer, or long-term clinic staff member) who is available to take part in certain assessments

Who may not be able to join:

  • People who have another mental health condition (besides schizophrenia) that has been the main cause of their symptoms or difficulties in daily life within the past 12 months
  • People who would be stopping a current antipsychotic medication that is working well and being tolerated, specifically in order to enter this trial
  • People who have received certain treatments that are not permitted during the screening period (unless those treatments are stopped before the study officially begins)
  • People who have a significant or unstable physical health condition identified at the time of screening or at the start of the study
  • People who have notable abnormal results from a physical examination, heart tracing (ECG), or blood/lab tests at screening or at the start of the study
  • People who are considered to be at elevated risk of suicidal behaviour
  • People who have a known allergy to the study drug (ML-007C-MA), its active ingredients, or any of its components
  • People who have been diagnosed with a moderate to severe substance use disorder in the past 12 months (not including tobacco or caffeine), as confirmed by a clinical interview
  • People whose history and the investigator's assessment suggest an elevated risk of violent or destructive behaviour

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: MapLight Therapeutics, MapLight Therapeutics

Phone: +1 650 839 4385

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
MapLight Therapeutics
Registry
ClinicalTrials.gov
Start date
31 March 2026
Est. completion
1 February 2030

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

To assess the safety and tolerability of long-term ML-007C-MA administration in adult participants with schizophrenia

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov