Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have signed a written consent form agreeing to take part in the study
• People who are at least 18 years old and able to understand the patient information provided
• People diagnosed with stage III high-grade serous ovarian cancer, fallopian tube cancer, or related cancer originating outside the ovary (based on the FIGO staging system)
• People with stage IV cancer may also be considered in specific situations, such as when the cancer has spread to a limited area of the bowel, the abdominal wall, or the belly button area and can be surgically removed, or when stage IV is based only on small lymph nodes near the heart and diaphragm that are less than 1cm in size
• People whose diagnosis has been confirmed through tissue sampling (biopsy) or fluid testing (cytology), with additional laboratory tests used to confirm the diagnosis if only fluid testing was used
• People who are planned for a specific type of surgery called interval cytoreductive surgery with HIPEC (a procedure that removes tumours and uses heated chemotherapy inside the abdomen), after receiving at least 3 rounds of a standard chemotherapy combination
• People whose cancer has not grown or spread during chemotherapy — it must be stable or have responded to treatment
• People whose suitability for surgery has been reviewed by a team of specialists using scans or a keyhole examination of the abdomen, and where complete or near-complete tumour removal is considered achievable
• People who are physically well enough for major surgery, with a general health score of 0–2 on the WHO scale (ranging from fully active to capable of some self-care)
• People with adequate bone marrow function, as shown by blood test results meeting specific minimum levels for red blood cells, white blood cells, and platelets (confirm with trial site for exact values)
• People with adequate liver function, based on blood tests showing liver enzyme and bilirubin levels within an acceptable range
• People with adequate kidney function, based on a kidney filtration measurement meeting a minimum threshold (confirm with trial site for exact method used)

Who may not be able to join:

• People who have previously been treated with chemotherapy for a different cancer
• People who wish to preserve their fertility and are seeking fertility-sparing surgery
• People who are currently taking certain strong medications that significantly affect how the body processes a specific group of drugs (called CYP3A4 inducers or inhibitors, as assessed using a Dutch medication reference tool), and where those medications cannot be temporarily stopped

Important: Always verify eligibility with the trial site directly before applying.