Phase 2 Pulmonary Hypertension Trial, Not Yet Recruiting NCT07473700 Sponsor: Tectonic Operating Company, Inc. Condition: Pulmonary Hypertension
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Phase 2 Pulmonary Hypertension Trial, Not Yet Recruiting

NCT07473700
Not Yet Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been diagnosed with a type of scarring lung disease (ILD), confirmed by a chest CT scan taken within the last 12 months, showing that at least 10% of your lung tissue is affected by scarring.
  • Your lung capacity (how much air your lungs can hold) falls within a specific range — not too low and not too high — as measured by a breathing test called spirometry (confirm with trial site for exact numbers).
  • You have had at least ONE of the following recent heart tests showing signs of raised pressure in the lungs: a right heart catheterization procedure within the last 18 months showing specific pressure readings, OR a heart ultrasound (echocardiogram) within the last 18 months showing elevated pressure in the right side of the heart, without significant problems with the left side of the heart.

Who may not be able to join:

  • You have been diagnosed with, or are suspected of having, certain other types of pulmonary hypertension (high blood pressure in the lungs) classified under specific medical groups (WHO Groups 1, 2, 4, or 5) (confirm with trial site).
  • You have taken certain medications for pulmonary hypertension — such as specific tablets, injections, or infusions — within the last 30 days, or a medication called sotatercept within the last 180 days.
  • You have certain other heart or lung conditions alongside your ILD (confirm with trial site for the full list of conditions).
  • You are taking medication to treat your scarring lung disease (such as anti-fibrotic, immunosuppressant, or anti-inflammatory drugs) but have not been on a stable, unchanged dose for at least 30 days, or you have started a new lung disease treatment within the last 90 days.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: +1 339 337 4053

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Not Yet Recruiting
Phase
Phase 2
Sponsor
Tectonic Operating Company, Inc.
Registry
ClinicalTrials.gov
Start date
30 March 2026
Est. completion
21 November 2027

Where this trial is recruiting

🇵🇱 Poland 🇷🇴 Romania 🇷🇸 Serbia 🇪🇸 Spain 🇺🇸 United States

Primary endpoints

Mean Change from Baseline in PVR up to 16 Weeks; Number of Participants with Adverse Events (AEs), Adverse Events of Special Interest (AESIs) and Serious Adverse Events (SAEs); Number of Participants with Clinically Significant Changes from Baseline in Safety Laboratory Assessments, 12-Lead Electrocardiogram (ECG) Assessments and Vital Sign Assessments

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov