Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years, of any sex
• People whose cancer of the esophagus (food pipe) or the junction between the esophagus and stomach has been confirmed by a laboratory test of tissue or cell samples, and is specifically the squamous cell type
• People who have not yet received any systemic (whole-body) anti-cancer treatment for their current recurrent or metastatic (spread) disease
• People who have at least one tumor that can be measured on a scan, according to standard criteria called RECIST 1.1
• People with a general health and activity level rated as 0 or 1 on a standard medical scale (meaning fully active or able to carry out light work)
• People expected to live longer than 12 weeks
• People with a Body Mass Index (BMI) of 16.0 or above
• People whose blood test results show their bone marrow, kidneys, and liver are functioning adequately
• Women who could become pregnant must have had a negative blood pregnancy test within 7 days before the first treatment dose
• People who are willing to take part voluntarily and sign a consent form

Who may not be able to join:

• People who have central nervous system (brain or spinal cord) metastases that are causing symptoms, have not been treated, or are actively getting worse
• People who have had another type of cancer in the past 5 years
• People with a known allergic reaction to any monoclonal antibody medicines or chemotherapy ingredients used in the trial
• People with certain abnormalities affecting the digestive tract (confirm with trial site)
• People at high risk of bleeding or of developing an abnormal opening (fistula) between the esophagus and nearby organs, or who already have an esophageal or tracheal fistula
• People with certain heart or blood vessel conditions (confirm with trial site for specific details)
• People who have previously been treated with anti-angiogenic drugs (medicines that block blood vessel growth to tumors) or immunotherapy
• People who have received any systemic cancer treatment, experimental drugs, or live vaccines within 4 weeks before the first dose; palliative radiotherapy within 2 weeks before enrollment; or major surgery within 28 days before enrollment
• People with uncontrolled fluid build-up around the lungs, heart, or abdomen that requires repeated draining
• People who still have unresolved side effects from previous cancer treatment that have not returned to a mild or absent level
• People with an active autoimmune disease, or a history of autoimmune disease that required systemic (whole-body) treatment
• People with active infections, including a serious infection within the past 4 weeks, active tuberculosis, or a positive test for HIV, hepatitis B, or hepatitis C
• Women who are pregnant or breastfeeding
• Women who could become pregnant, or men who could father a child, who do not agree to use contraception during the trial and for 6 months after it ends
• People who have other conditions that the trial doctor judges would increase safety risks or affect the reliability of the trial results

Important: Always verify eligibility with the trial site directly before applying.