Phase 3 Macular Degeneration Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are able and willing to give your consent to participate (or have a legal representative who can do this on your behalf), and you are able to follow the study schedule and requirements
• You have been diagnosed with a specific type of abnormal blood vessel growth in the eye (called CNV) caused by wet age-related macular degeneration (wet AMD) in the eye being studied, and the condition was active at your first screening visit
• You are at least 50 years old at the time of your first screening visit
• Your vision in the study eye falls within a specific range — roughly between 20/200 and 20/32 on a standard eye chart (confirm with trial site if unsure where your vision falls)
• Your eye showed a meaningful improvement in its structure when treated with anti-VEGF injections (a common wet AMD treatment) during the screening period
• You are able to reliably use eye drops as required by the study

Who may not be able to join:

• You have a medical condition that the doctor believes could make the study treatment unsafe for you, make it hard for you to take part, or affect the study results — this may include a history of severe COVID-19 if it is likely to cause complications
• You have previously received any type of gene therapy
• You have taken part in a clinical trial using an experimental medicine or medical device in your study eye within the past 3 months (or longer, depending on the medicine)
• You are pregnant, breastfeeding, or planning to become pregnant or breastfeed in the future
• You have had a heart attack in the 6 months before the start of the study
• You have high blood pressure that is not well controlled (confirm specific numbers with trial site)
• You have had a stroke in the 6 months before the start of the study
• You have an ongoing bleeding disorder (note: taking aspirin or certain blood thinners is generally allowed)
• You have been taking immune-suppressing medications within the past 90 days — though short courses of steroids by mouth, or steroid use through inhaler, joints, nose spray, or skin cream, may be allowed
• You have poorly controlled diabetes, or your blood sugar levels (measured by a specific blood test called HbA1c) are too high during screening
• You have an active eye or surrounding eye area infection in your study eye
• You have had eye surgery (including laser or corrective surgery) in your study eye within the past 5 months, or have ever had certain specific eye surgeries such as a cornea transplant, removal of the gel inside the eye (vitrectomy), or certain laser or surgical treatments for macular degeneration
• You have a history of a detached retina or a tear in a specific layer of your eye (the retinal pigment epithelium) in the study eye
• You have uncontrolled pressure inside your eye (glaucoma) in the study eye, are using two or more eye drops to lower eye pressure, or have had certain glaucoma surgeries in the study eye
• You have ever had increased eye pressure caused by steroid eye drops in either eye
• You have a history of eye inflammation (uveitis) in either eye, beyond mild post-surgical swelling that went away
• You have ever been treated with a specific type of medication called a complement inhibitor for a condition called geographic atrophy in your study eye
• You have a known history of certain viral eye infections (such as herpes or cytomegalovirus affecting the eyes) in either eye

Important: Always verify eligibility with the trial site directly before applying.