Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be at least 18 years old (or the legal adult age in your country)
• You have been diagnosed with one of these advanced, recurring, or spreading cancers that tests positive for specific proteins called B7-H3 and PTK7: non-small cell lung cancer, esophageal squamous cell cancer, endometrial cancer, a type of ovarian cancer (HGSOC), head and neck cancer (HNSCC), triple-negative breast cancer, colorectal cancer, or a type of prostate cancer (CRPC) — and your cancer has continued to grow or come back after at least one previous treatment, or you cannot tolerate further standard treatment
• You have a stored tissue sample available from a previous biopsy or surgery for testing
• Your cancer can be measured on a scan
• You are in good enough general health to carry out daily activities with little to no limitation (confirmed by a standard health scoring system)
• Your bone marrow, liver, kidneys, and other organs are functioning well enough
• You are able to follow the study's requirements around contraception or barrier methods

Who may not be able to join:

• You have brain or spinal fluid metastases that are causing symptoms
• You have a cancer that started in the brain, or you have had another type of cancer within the past 2 years
• You have cancer-related pain that is not well controlled
• You have had a significant heart problem or a stroke within the past 6 months
• You currently have an active infection that is not under control
• You have a history of lung inflammation (pneumonitis), are currently being treated with steroids for a non-infectious lung condition, have suspected lung inflammation seen on recent scans, or have had a moderate to severe lung disease affecting your breathing in the past 3 months
• You have had a serious infection requiring a hospital stay (such as blood infection or severe pneumonia) within the past 4 weeks
• You have a weakened immune system or test positive for HIV at screening
• You have a known or suspected hepatitis B or C infection
• You have had active tuberculosis within the past year
• You still have significant side effects from a previous cancer treatment that have not improved to a mild level (with the exception of some nerve-related symptoms) (confirm with trial site)
• You have received chemotherapy within 3 weeks, immunotherapy or targeted cancer treatment within 3 weeks, or another experimental treatment within 4 weeks before starting this trial
• You currently take or need to take certain medications or foods that strongly affect how the body processes drugs (confirm with trial site)
• You have previously been treated with a drug that targets B7-H3 or PTK7 in a specific type of therapy called an antibody-drug conjugate (ADC)
• You have had a specific type of cancer treatment called a topoisomerase I inhibitor within the past 6 months
• You have had radiotherapy within the past 2 weeks
• You have had major surgery or a significant injury within the past 4 weeks
• You have received a live vaccine within the past 28 days or plan to receive one during the study
• You are currently pregnant, breastfeeding, or planning to become pregnant during the study or within 7 months after your last dose
• You have a known allergy to any ingredient in the study drug, or have had a severe allergic reaction to a similar type of drug before
• You have certain eye conditions, including corneal ulcers or severe dry eye

Important: Always verify eligibility with the trial site directly before applying.