Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with esophageal squamous cell carcinoma (a specific type of oesophageal cancer) confirmed by laboratory testing
• People aged between 18 and 80 years, of any gender
• People whose general physical condition is rated as reasonably functional (on a standard medical scale), and who have not lost more than 10% of their body weight in the past 6 months
• People whose cancer has been assessed as locally advanced and not removable by surgery, based on established medical guidelines
• People whose treatment plan includes surgery after an initial course of therapy to try to shrink the tumour, and who have no medical reasons preventing surgery
• People who have not previously received any treatment for this cancer, including radiation, chemotherapy, or surgery
• People who have at least one measurable tumour area based on standard imaging criteria
• People whose expected survival is at least 3 months
• People who are able to swallow and take oral medications
• People whose blood counts, organ function, and other laboratory results meet the levels required by the trial
• Women who could become pregnant, and men, who agree to use effective contraception throughout the trial and for 6 months after it ends
• People who are willing to participate voluntarily and have signed a consent form

Who may not be able to join:

• People who have a fistula (an abnormal connection) between the oesophagus and the airway or chest cavity, or whose tumour is growing into major blood vessels in a way that could cause life-threatening bleeding
• People who have had another type of cancer in the past 5 years
• People who have used medications that suppress the immune system, or steroid medications above a certain dose, within 2 weeks before starting the trial
• People who have an active autoimmune disease, or a history of autoimmune disease that has required ongoing medical treatment
• People with a known history of immune system deficiency, including HIV infection, or those who have had an organ transplant or bone marrow transplant
• People with other serious uncontrolled health conditions, such as uncontrolled high blood pressure, unstable heart conditions, a recent heart attack, or severe infections
• People with active tuberculosis (TB), or a history of TB that was not fully treated
• People with active Hepatitis B or Hepatitis C infection
• People who are completely unable to take any nutrition or medication by mouth due to severe narrowing of the oesophagus
• People who have, or have had, significant scarring or inflammation in the lungs (interstitial lung disease)
• People with uncontrolled fluid build-up around the lungs, heart, or abdomen that requires repeated draining
• People with significant bowel problems causing severe diarrhoea
• People who are pregnant or currently breastfeeding
• People who have taken part in another clinical trial within the 30 days before enrolling

Important: Always verify eligibility with the trial site directly before applying.