Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a specific type of brain lymphoma called primary central nervous system diffuse large B-cell lymphoma (PCNSL-DLBCL), confirmed through laboratory testing of tissue.
• People whose cancer has come back or stopped responding after previous treatment with high-dose methotrexate and/or a type of drug called a BTK inhibitor.
• People aged between 18 and 75 years.
• People with a general health and functioning level ranging from fully active to completely dependent (covering a wide range of physical ability — confirm with trial site).
• People whose doctors expect them to live for more than 3 months.
• People with no known allergic reactions to any of the drugs used in this study.
• People whose blood cell counts meet minimum levels: white blood cells at or above 3×10⁹/L, neutrophils at or above 1.0×10⁹/L, and platelets at or above 50×10⁹/L.
• People whose kidneys are functioning at an adequate level, based on specific blood and urine measurements.
• People whose liver is functioning at an adequate level, based on specific blood test results.
• People who have read, understood, and signed a consent form agreeing to take part.

Who may not be able to join:

• People who currently have another type of cancer that requires active treatment with medication or surgery.
• People who are pregnant or breastfeeding.
• People who are capable of having children but are unwilling or unable to use effective contraception during the study.
• People with a known allergy or sensitivity to any of the study drugs or their ingredients.
• People who have an active infection at the time of joining (as assessed by the study doctor).
• People with a history of immune system problems, including HIV, other immune deficiency conditions present from birth or developed later, or a history of organ transplantation.
• People with a documented history of certain neurological or psychiatric conditions, including epilepsy or dementia.
• People with a documented history of autoimmune diseases, with the exception of certain thyroid conditions (Hashimoto's thyroiditis or thyroid dysfunction).
• People with any serious other health condition that, in the study doctor's judgment, could put them at risk or affect their ability to complete the trial.

Important: Always verify eligibility with the trial site directly before applying.