Phase 3 Stroke Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 80 years old
- You have been diagnosed with an acute ischaemic stroke (a stroke caused by a blocked blood vessel), confirmed by a CT or MRI scan
- You have received or are planned to receive a clot-dissolving medication given through a drip (IV) either within 4.5 hours of your stroke starting, or within 4.5 to 24 hours based on your doctor's guidelines
- The study drug can be given to you before or within 2 hours of starting the clot-dissolving treatment
- Your stroke severity falls within a specific range on a standard medical scale, and you had little or no difficulty with consciousness before treatment (confirm with trial site)
- You are willing and able to sign a consent form agreeing to take part
Who may not be able to join:
- You had some level of physical disability before this stroke, based on a standard disability scale (confirm with trial site)
- You have a history of a serious bowel condition called pseudomembranous colitis or colitis caused by antibiotics
- You are known to be allergic or sensitive to a group of antibiotics called tetracyclines, or to minocycline specifically
- You are known to be resistant to other tetracycline-type antibiotics
- You have taken tetracycline antibiotics in the past 7 days
- You currently have a known bacterial infection such as pneumonia or a urinary tract infection that requires antibiotic treatment
- You have had a bleed in or around the brain in the past 3 months (such as a brain bleed or blood clot on the brain)
- Your brain scan shows a tumour, abscess, abnormal blood vessel, or another major brain condition that is not stroke-related
- Your stroke is thought to be caused by a rare or unclear reason, such as a torn blood vessel or inflamed blood vessels (confirm with trial site)
- You have a history of systemic lupus erythematosus (an immune system disease)
- You have severe liver or kidney problems, based on specific blood test results (confirm with trial site)
- You have used certain skin or hormone-related medications, including tretinoin or anabolic steroids, in the past 3 months (confirm with trial site)
- You are pregnant, breastfeeding, or able to become pregnant and are not willing to use effective contraception throughout the study
- You have a serious non-stroke-related illness where your life expectancy is less than 6 months
- You have taken part in another clinical trial in the past 30 days
- You have a physical, cognitive, emotional, or mental condition that would prevent you from understanding or following the study procedures
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Yilong Wang, MD, PhD, Beijing Tiantan Hospital
Phone: 8601059976951
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Excellent functional outcome (mRS of 0-1)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 5 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.