Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who have been diagnosed with a specific type of blood cancer called large B-cell lymphoma (LBCL), including certain subtypes, confirmed by a tissue sample (biopsy)
• People whose lymphoma has come back or stopped responding to treatment, and who have already received at least 2 different systemic (whole-body) treatments
• People whose condition makes them suitable for a type of targeted radiation therapy of up to 20 Gray (a unit of radiation), applied to up to 3 affected areas
• People who have at least two measurable areas of disease, including at least one area that has never been treated with radiation and will not be radiated as part of this trial
• People with a general health and activity level rated at 3 or below on a standard medical scale (ECOG), meaning someone may be limited in activity but is still up and about for some of the day (confirm with trial site)
• People whose blood counts meet minimum levels: white blood cells (neutrophils) at or above a certain threshold, platelets at or above a certain level, and haemoglobin at or above 7 g/dL — supporting medications and transfusions are permitted to help meet these levels
• People whose liver function blood test results are within acceptable ranges, with slightly higher limits allowed for people who have cancer that has spread to the liver
• People whose kidney function meets a minimum level, as measured by a standard calculation called the Cockcroft-Gault formula
• People who either are not able to become pregnant, or who have a negative pregnancy test result before joining; and people who agree to use highly effective contraception if there is any possibility of pregnancy (for themselves or their partner) during the trial
• People who have reached menopause, which is defined by specific criteria depending on age and hormonal history (confirm with trial site for the exact requirements)
• People whose side effects from any previous cancer treatment have either gone away or have been assessed by their doctor as stable
• People who are able to understand the study information and are willing to give written consent to participate

Who may not be able to join:

• People who are currently receiving any other approved or experimental treatment for lymphoma, except for corticosteroids (a type of anti-inflammatory medication)
• People whose lymphoma got worse while receiving a specific type of treatment called a CD20 x CD3 bispecific antibody (note: having received this type of treatment in the past is allowed, as long as the disease did not progress on it)
• People who received certain systemic cancer treatments — particularly those with long-lasting effects such as some immune therapies — within 14 days or within five half-lives of starting the trial, whichever is the shorter period
• People who have been diagnosed with another type of cancer that, in the doctor's judgement, could affect their safety or ability to take part in the trial
• People with cancer that has spread to the brain or the tissue surrounding the brain and spine — though people whose brain involvement was treated with radiation or surgery and has been stable for at least 4 weeks may still be considered (confirm with trial site)
• People with serious medical conditions that, in the doctor's opinion, would make the risks of joining the trial outweigh the potential benefits
• People who have an active infection (bacterial, viral, fungal, or other) that requires treatment at the time of screening
• People with HIV who have had a detectable level of the virus in their blood within the past 6 months — though people on effective HIV treatment with an undetectable viral load within the past 6 months may still be considered eligible by the trial site
• People with active Hepatitis B infection — though people with a past Hepatitis B infection that has resolved may be considered eligible (confirm with trial site); people with Hepatitis C antibodies may be considered eligible only if a specific test shows no active virus in the blood
• People with medical, psychiatric, thinking, or other conditions that could affect their ability to understand the study, give consent, or follow the study requirements
• People who are unable to tolerate corticosteroid medications
• People who are taking certain medications that are not permitted during the trial (confirm prohibited medications with the trial site)

Important: Always verify eligibility with the trial site directly before applying.