Phase 3 Ankylosing Spondylitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

If you have a fever of unknown cause:

• You have been ill for more than 3 weeks
• You have had a high temperature (above 38.3°C) on more than 3 occasions, or blood tests have shown signs of inflammation on more than 3 occasions
• Doctors have not been able to find the cause despite standard initial tests

If you may have a condition called IgG4-related disease (IgG4-RD):

• An experienced specialist strongly suspects you have this condition based on your symptoms, examination, and test results
• You have recently been diagnosed with IgG4-RD through a tissue sample (biopsy) and need further scans to check how far the condition has spread
• You have a previously confirmed diagnosis of IgG4-RD and a specialist believes it has come back

If you may have a condition causing inflammatory back pain (axial spondyloarthropathy):

• An experienced rheumatology specialist strongly suspects you have this condition based on symptoms such as back pain lasting more than 3 months, stiffness in the morning, pain that improves with movement but worsens with rest, pain at night, and onset before age 45
• You still have ongoing inflammatory back pain after trying 2 different types of standard anti-inflammatory painkillers (each tried for 2–4 weeks), and you are therefore being considered for a stronger type of medication called biological therapy

Who may not be able to join:

• You are not able to fully understand the study or are unwilling or unable to take part in all required procedures
• You have another condition or disorder that the study doctor feels could put your safety at risk or affect your ability to follow the study plan
• You are currently receiving or have previously received a treatment that the study doctor feels could affect your safety or the reliability of the trial results
• You are pregnant (a urine pregnancy test will be done if applicable), breastfeeding, planning to become pregnant, or you could become pregnant and are not using a reliable, highly effective form of contraception (confirm with trial site for specific accepted methods)
• You are already taking part in another clinical trial involving an experimental medicine or device, unless the study team considers both trials to be compatible
• You have taken part in a scientific study in the last 12 months where the experimental procedures exposed you to more than 1 mSv of radiation
• You have a known allergy or sensitivity to the imaging agent used in this trial, called [¹⁸F]AlF-FAPI-74, or any of its ingredients
• You have already started active treatment for the condition being studied

Important: Always verify eligibility with the trial site directly before applying.