Phase 1 Prostate Cancer Trial, Recruiting NCT07545811 Sponsor: Janux Therapeutics Condition: Prostate Cancer
Back to Prostate Cancer

Phase 1 Prostate Cancer Trial, Recruiting

NCT07545811
Recruiting Phase 1

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who are male and aged 18 or older at the time of signing the consent form
  • People who have been diagnosed with prostate cancer (adenocarcinoma type), confirmed through laboratory testing of tissue or cell samples
  • For the dose escalation part of the trial: People whose prostate cancer has spread and is no longer responding to hormone therapy, and who have previously been treated with at least one newer hormone-blocking drug and at least one chemotherapy regimen containing a taxane drug — or who have declined taxane chemotherapy or been assessed as medically unsuitable to receive it
  • For the dose expansion part of the trial: People who have received no more than two hormone-blocking therapies and no more than one prior taxane chemotherapy regimen at an earlier stage of their disease — or who have declined taxane chemotherapy or been assessed as medically unsuitable to receive it
  • People whose liver, kidneys, and other organs are functioning at an adequate level (confirm with trial site)

Who may not be able to join:

  • People who have previously received a solid organ transplant (such as a kidney, liver, or heart transplant)
  • People who have previously received a type of immune cell treatment called CAR-T cell therapy, or certain other immune-based cancer therapies (approved or experimental), or a type of treatment called radioligand therapy
  • People with serious heart or blood vessel disease

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 20 July 2026
Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: +1 858-206-8471

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 1
Sponsor
Janux Therapeutics
Registry
ClinicalTrials.gov
Start date
15 April 2026
Est. completion
1 May 2028

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Incidence of Dose Limiting Toxicities (DLTs); Incidence of adverse events (AE) and Serious Adverse Events (SAE)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov