Phase 3 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a woman aged 18 or older
• You have been diagnosed with a specific type of ovarian, peritoneal, or fallopian tube cancer (high-grade serous type)
• Your cancer can be measured on scans, following a standard set of measurement guidelines
• You are generally active and able to care for yourself, with only minor limitations on daily activities (confirm with trial site)
• A test of your tumor tissue has shown a specific protein called "cyclin E1" is present, using a special test approved for this trial
• Your cancer has stopped responding to platinum-based chemotherapy (known as platinum-resistant disease)
• You have received between 1 and 3 previous treatment regimens (or up to 4 if one of them included a drug called mirvetuximab)
• You have previously received a drug called bevacizumab, if your doctors considered it appropriate for you
• You have previously received a type of drug called a PARP inhibitor, if your cancer has a BRCA gene mutation or similar issue and your doctors considered it appropriate
• You have previously received mirvetuximab, if your doctors considered it appropriate for you
• Your blood counts and organ functions (such as kidneys and liver) are at acceptable levels during the screening period

Who may not be able to join:

• You have had another cancer in the past 2 years, unless it was fully cured by surgery alone and has not come back (some exceptions may apply — confirm with trial site)
• Your cancer never responded to platinum-based chemotherapy from the very start (rather than stopping working over time)
• You have previously been treated with azenosertib or certain other specific targeted drugs (WEE1, ATR, CHK1/2, or PKMYT1 inhibitors) for this cancer
• You have brain tumors that are causing symptoms or need immediate treatment (those with brain tumors that are not causing symptoms may still be eligible — confirm with trial site)
• You have a serious kidney problem currently requiring medical intervention, or you have a urinary catheter or kidney drain in place
• You have significant stomach or bowel problems that prevent you from swallowing pills, or you require nutrition given directly into a vein
• There is evidence of a blockage in your small bowel, you were hospitalized for a bowel blockage in the past 3 months, or you have needed repeated fluid drainage from your abdomen or chest in the past 6 weeks
• You have an active infection that has not been fully treated and cleared for at least 7 days before joining the trial
• You have heart failure of a moderate to severe level (confirm with trial site)
• You have a medical or mental health condition, or abnormal lab results, that the trial doctors believe could make participation unsafe or affect results
• You were hospitalized in the 14 days before joining the trial
• You had major surgery within the past 28 days
• You received chemotherapy or certain other cancer treatments within the past 21 days (or within 5 half-lives of the drug, whichever is shorter)
• You received radiation therapy within the past 21 days
• You had a stem cell transplant within the past 3 months
• You are currently taking another experimental drug as part of a different trial (within 28 days or 5 half-lives, whichever is shorter)
• You are unable to stop taking certain medications, foods, or herbal supplements that are not allowed during this trial (confirm with trial site for the specific list)
• You previously received radiation treatment covering a large portion (20% or more) of your bone marrow
• You still have significant side effects (Grade 2 or higher) from previous cancer treatments, with some exceptions such as mild nerve problems, hair loss, or skin color changes
• You have a weakened immune system, or you are HIV-positive and on anti-retroviral therapy
• You have an active hepatitis B or hepatitis C infection
• The trial doctors have determined for any other reason that the trial is not appropriate for you (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.