Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older of any gender
• People who have been confirmed by tissue testing to have MALT lymphoma (a type of slow-growing lymphoma that starts in organs outside lymph nodes), with at least one affected area larger than 1.0 cm that can be measured, located outside the spleen
• People who have not yet received any systemic anti-cancer treatment (such as chemotherapy, targeted therapy, or rituximab) since their diagnosis — with a note that people whose lymphoma progressed or came back after local treatments (such as surgery, antibiotic treatment for stomach bacteria, or hepatitis C treatment) may still be eligible; for stomach MALT lymphoma specifically, the stomach bacteria called Helicobacter pylori must either be absent or have not responded to standard treatment (confirm with trial site)
• People who are generally well enough to carry out normal daily activities with little or no limitation (based on a standard medical scale scored 0 or 1)
• People whose doctor has determined that treatment is needed, based on symptoms, low blood counts, risk of organ damage, a large disease burden, or ongoing disease progression
• People whose blood counts and organ function meet specific minimum levels — including adequate levels of white blood cells, platelets, and red blood cells, as well as acceptable liver, kidney, and pancreas function, and normal blood clotting levels (confirm specific values with trial site)
• People with an expected survival of at least 3 months
• People who are willing and able to give written consent before any screening begins

Who may not be able to join:

• People who currently have, or have previously had, another type of cancer, unless it was fully treated and has completely resolved
• People whose lymphoma has spread to the brain or spinal cord, or whose lymphoma has changed into a more aggressive (high-grade) form
• People who have had treatment for another cancer and are still experiencing significant side effects from that treatment (above a mild level), not including hair loss
• People with serious or uncontrolled heart conditions, including moderate-to-severe heart failure, unstable chest pain, a heart attack in the past 6 months, heart rhythm problems requiring treatment, a weakened heart pump function, certain structural heart muscle diseases, a history of a specific abnormal heart electrical measurement (QTc interval), heart artery disease requiring medication, or high blood pressure that cannot be adequately controlled even with multiple medications
• People who have had significant active bleeding in the 2 months before screening, are currently taking blood-thinning medications, or are assessed by their doctor as having a clear risk of bleeding
• People with high levels of protein in their urine, above certain measured thresholds (confirm with trial site)
• People who have had a blood clot in a deep vein or in the lungs within the past 6 months
• People who have had an organ transplant or a bone marrow/stem cell transplant from another person
• People who have had major surgery (performed under general anaesthetic) within 6 weeks before screening, or minor surgery within 2 weeks before screening — though placement of a vascular access device and diagnostic camera examinations are not counted as exclusions
• People living with HIV/AIDS or other serious infectious diseases
• People with severe lung function problems caused by conditions such as pulmonary fibrosis, interstitial lung disease, dust-related lung disease, or lung damage from radiation or medication
• People who have previously been treated with certain targeted drugs that affect specific cell signalling pathways involved in lymphoma (BTK inhibitors, BCR pathway inhibitors such as PI3K or Syk inhibitors, or BCL-2 inhibitors)
• People with a history of drug or alcohol misuse
• People who are pregnant or breastfeeding, or people who could become pregnant and are unwilling to use contraception during the trial
• People who, in their doctor's judgement, have any other condition that makes participation in this trial unsuitable

Important: Always verify eligibility with the trial site directly before applying.