Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Male patients aged 18 years or older
• People with prostate cancer that has been confirmed by tissue testing and is considered high-risk, based on at least one of the following: a high aggressiveness score (ISUP Grade Group 4 or 5); scan findings suggesting the cancer may be spreading beyond the prostate on one side; or a PSA blood test result of 20 ng/mL or higher with the cancer mainly on one side
• People whose cancer appears to be on one side of the prostate only, based on biopsy results and specialised scans (MRI and PSMA PET)
• People whose specialised nuclear medicine scan (PSMA PET) does not show cancer spread to lymph nodes on the opposite side to the main cancer
• People with no significant cancer activity detected on the opposite side of the prostate on PSMA PET scan
• People with no confirmed cancer lesion on the opposite side of the prostate on MRI or biopsy
• People with no high-risk or unusual cancer tissue found on the opposite side of the prostate
• People with no sign of the cancer breaking through the prostate capsule or invading the seminal vesicles on the opposite side
• People with a limited number of low-to-intermediate risk biopsy samples on the opposite side (up to two cores with unfavorable intermediate-risk disease, or up to four with favorable intermediate-risk disease) (confirm with trial site)
• People with no more than two lymph nodes showing cancer activity on the same side as the main cancer on PSMA PET
• People whose cancer appears confined to the prostate with no spread to distant sites or lymph nodes further away from the pelvis, confirmed by scans
• People whose doctor estimates a life expectancy of more than 10 years
• People who are scheduled for robot-assisted surgical removal of the prostate and are considered medically fit for surgery
• People who have provided written consent to participate

Who may not be able to join:

• People who have had any prostate cancer treatment before surgery, including hormone therapy, chemotherapy, radiation, or any procedure to destroy prostate tissue
• People who have previously had active treatment for prostate cancer
• People with high-grade cancer (ISUP Grade Group 4 or 5) on the opposite side of the prostate
• People with certain amounts of intermediate-grade cancer on the opposite side of the prostate (more than four cores graded ISUP 2, or more than two cores graded ISUP 3)
• People whose scans suggest the cancer has spread beyond the prostate on the opposite side
• People whose scans show cancer has spread to lymph nodes or distant sites, except for up to two pelvic lymph nodes on the same side as the main cancer
• People who have not had a sufficient prostate biopsy performed (a minimum of 10 cores is required, plus targeted samples when a target lesion is visible)
• People with another currently active cancer
• People who are unable to have MRI or PSMA PET scans for medical reasons
• People who are unable to provide written informed consent
• People aged under 18 years
• People with a high anaesthetic risk score (ASA score greater than 3), indicating significant health concerns related to surgery
• People with any medical reason that makes removal of pelvic lymph nodes unsafe
• People with severe psychiatric illness
• People with blood or clotting function that does not meet the required levels
• People with an active infection
• People with any serious medical, psychiatric, psychological, personal, or logistical condition that, in the investigator's judgement, could interfere with treatment, follow-up, or safety
• People with a prior cancer that was treated with curative intent may only be considered if a local specialist multidisciplinary tumour board provides mandatory approval

Important: Always verify eligibility with the trial site directly before applying.