Phase 3 Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who had little or no disability before the stroke (able to carry out usual activities with at most minor symptoms)
• People whose stroke symptoms began within the last 24 hours, including strokes noticed upon waking or strokes where no one witnessed the exact moment symptoms started (the starting time is counted from when the person was last known to be well)
• People whose stroke symptoms are rated as moderately severe or worse on a standard stroke scale (NIHSS score of 6 or higher)
• People whose brain imaging shows that a significant portion of the brain tissue in the back part of the brain is still potentially recoverable (confirm with trial site for exact imaging score details)
• People whose stroke is caused by a blockage in one of the main arteries supplying the back of the brain (the vertebral or basilar artery), confirmed by specialised blood vessel imaging
• People in whom blood flow through the blocked artery has been successfully restored — either by a clot-removal procedure or by natural improvement seen on imaging before any procedure was needed
• People, or their legally authorised representative, who are able to give written consent to participate

Who may not be able to join:

• People who have active bleeding inside the brain shown on a scan
• People whose imaging shows blockages in both the front and back blood vessel systems of the brain (unless they have a previous history of a front-of-brain blockage)
• People whose scans show complete damage to specific deep brain structures on both sides (both thalami or both sides of the brainstem)
• People whose scans show a cerebellar stroke causing significant swelling or pressure on a nearby part of the brain
• People whose blood vessel anatomy is too twisted, irregular, severely narrowed, or torn to allow the clot-removal devices to reach the blocked vessel safely
• People with a history of a serious bowel condition linked to antibiotic use (pseudomembranous or antibiotic-associated colitis)
• People with a known allergy to tetracycline-type antibiotics, any ingredient in the study drug, contrast dye used in imaging, or a metal called nitinol (used in some medical devices)
• People whose stroke-causing bacteria are known to be resistant to tetracycline antibiotics
• People who have taken tetracycline-type antibiotics in the 7 days before joining the trial
• People who have had any bleeding inside the brain or skull in the past 3 months (including various types of brain bleeds)
• People who have a brain tumour, abnormal blood vessel growth in the brain, or other space-occupying lesion inside the skull
• People who have had brain or spinal surgery in the past 3 months
• People who have had major surgery or a serious physical injury in the past month
• People who have received certain hormone-related treatments (including systemic vitamin A-related drugs, anabolic steroids, spironolactone, or androgen/anti-androgen therapies) in the past 3 months
• People with a low platelet count in their blood (below a specified level)
• People with severe liver failure, who are on regular dialysis, or who have severely reduced kidney function
• People who are pregnant, breastfeeding, or whose pregnancy test is positive before joining the trial
• People whose life expectancy is less than 6 months due to another serious illness such as cancer or severe heart or lung disease
• People already participating in another interventional clinical trial that could affect how results are measured
• People who, in the treating doctor's judgement, are unsuitable for any other reason — for example, due to difficulty understanding or following study procedures because of a psychiatric, cognitive, or emotional condition

Important: Always verify eligibility with the trial site directly before applying.